Author(s): Gayatri D Patil, Aditya R Nikam, Paresh A. Patil, Aakash D. Sonar

Email(s): drjigarvyas@gmail.com

DOI: 10.52711/0975-4377.2021.00054   

Address: Gayatri D Patil, Aditya R Nikam, Paresh A. Patil, Aakash D. Sonar
Ahinsa Institute of Pharmacy, Dondaicha 425408.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2021


ABSTRACT:
The treatment of brain disorders is particularly challenging due to the presence of a variety of formidable obstacles to deliver drugs selectively and effectively to the brain. Blood-brain-barrier (BBB) constitutes the major obstacle to the uptake of drugs into the brain following systemic administration. An intranasal delivery provides some drugs with short channels to bypass the blood-brain barrier (BBB), especially for those with fairly low brain concentrations after a routine delivery, thus greatly enhancing the therapeutic effect on brain diseases. The nasal mucosa is nearby the brain, cerebrospinal fluid (CSF) and the drug concentrations can exceed plasma concentrations. a longer retention time at the nasal mucosal surface, penetration enhancement of the active through the nasal epithelia, and a reduction in drug metabolism in the nasal cavity. Indications where nose-to-brain products are likely to emerge first include the following: neurodegeneration, post-traumatic stress disorder, pain, and glioblastoma.


Cite this article:
Gayatri D Patil, Aditya R Nikam, Paresh A. Patil, Aakash D. Sonar. Nose to Brain Drug Delivery System. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(4):335-0. doi: 10.52711/0975-4377.2021.00054

Cite(Electronic):
Gayatri D Patil, Aditya R Nikam, Paresh A. Patil, Aakash D. Sonar. Nose to Brain Drug Delivery System. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(4):335-0. doi: 10.52711/0975-4377.2021.00054   Available on: https://rjpdft.com/AbstractView.aspx?PID=2021-13-4-11


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