Author(s):
Omraje A. Jadhav, Rajendra K. Surawase., Yogesh Purkar., Shubham Bhadane., Sayali Shelar
Email(s):
Email ID Not Available
DOI:
10.52711/0975-4377.2024.00046 
Address:
Omraje A. Jadhav, Rajendra K. Surawase., Yogesh Purkar., Shubham Bhadane., Sayali Shelar
Loknete Dr. J. D. Pawar College of Pharmacy Manur, Kalwan.
*Corresponding Author
Published In:
Volume - 16,
Issue - 3,
Year - 2024
ABSTRACT:
The most effective and approved method of medicine delivery was orally administered. Because oral controlled-release dose forms provide major therapeutic benefits, the pharmaceutical industry advocates greater medical benefits as a primary stance. Many efforts have been undertaken recently to improve oral dosage forms' therapeutic efficacy and medication bioavailability. In this regard, a number of gastro-retentive drug delivery systems (GRDDS) have been employed to enhance the therapeutic efficacy of medications with a limited window for absorption, instability at alkaline pH, solubility in acidic environments, and localized activity in the stomach. We go over the physiological condition of the stomach and the several elements that influence GRDDS in this overview. The benefits and drawbacks of recently developed gastrointestinal technologies, including expandable, super porous hydrogel, bio/mucoadhesive, magnetic, ion-exchange resin, and low- and high-density systems, have also been studied. Additionally, new directions for this technology are explored in order to reduce the rate at which food leaves the stomach during both fed and fasted conditions. Overall, formulation scientists may find this review useful in guiding and informing their design of the GRDDS.
Cite this article:
Omraje A. Jadhav, Rajendra K. Surawase., Yogesh Purkar., Shubham Bhadane., Sayali Shelar. Gastro-Retentive Drug Delivery System: A Comprehensive Review and Future Perspectives. Research Journal of Pharmaceutical Dosage Forms and Technology.2024; 16(3):293-8. doi: 10.52711/0975-4377.2024.00046
Cite(Electronic):
Omraje A. Jadhav, Rajendra K. Surawase., Yogesh Purkar., Shubham Bhadane., Sayali Shelar. Gastro-Retentive Drug Delivery System: A Comprehensive Review and Future Perspectives. Research Journal of Pharmaceutical Dosage Forms and Technology.2024; 16(3):293-8. doi: 10.52711/0975-4377.2024.00046 Available on: https://rjpdft.com/AbstractView.aspx?PID=2024-16-3-15
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