Author(s): Riyaz Khan, Wajid Ahmad, Razia Pathan, Vishal Jain, Dipali Rajput

Email(s): wajidahmad806@gmail.com

DOI: 10.52711/0975-4377.2024.00020   

Address: Riyaz Khan1*, Wajid Ahmad1, Razia Pathan2, Vishal Jain2, Dipali Rajput2
1Department of Pharmaceutics, School of Pharmacy, Amravati – 444606.
2Department of Pharmaceutics, Institute and Research College of Pharmacy, Paratwada – 444606.
*Corresponding Author

Published In:   Volume - 16,      Issue - 2,     Year - 2024


ABSTRACT:
A sustained release system for Sumatriptan designed to increase its residence time in the stomach without contact with the Microspheres was achieved through the preparation of floating Microspheres by the Modified Emulsion solvent Diffusion method. In the present study attempt has been made to develop sustained released drug delivery system by formulating the floating Microspheres of Sumatriptan using White Rice Flour powder as a natural polymer which is biodegradable, biocompatible, nontoxic, economically cheap cost, devoid of adverse and side effects and easily availability. Sumatriptan Succinate is the succinate salt form of sumatriptan, a member of the triptan class of compounds with anti-migraine property. Sumatriptan succinate selectively binds to and activates serotonin 5-HT1 receptors. The 12 batches of floating Microspheres (MF1 to MF12) were formulated by Modified Emulsion solvent Diffusion method using different ratio of polymers like White Rice Flour power, HPMC K4M and Carbopol. The formulated Microspheres were evaluated by means of different parameters like shape and density of Microsphere, drug content uniformity, In-vitro buoyancy, swelling Index, In-vitro dissolution studies. The formulation MF6 has better sustained release when compared other formulations, hence we conclude that the combination of White Rice Flour powder, HPMC K4M shows better Gastric retention time which sustains the release of the dosage form.


Cite this article:
Riyaz Khan, Wajid Ahmad, Razia Pathan, Vishal Jain, Dipali Rajput. Effect of White Rice Flour in the Formulation Development and Evaluation of Sumatriptan Succinate Floating Microspheres by Modified Emulsion Solvent Diffusion Method. Research Journal of Pharmaceutical Dosage Forms and Technology.2024; 16(2):127-2. doi: 10.52711/0975-4377.2024.00020

Cite(Electronic):
Riyaz Khan, Wajid Ahmad, Razia Pathan, Vishal Jain, Dipali Rajput. Effect of White Rice Flour in the Formulation Development and Evaluation of Sumatriptan Succinate Floating Microspheres by Modified Emulsion Solvent Diffusion Method. Research Journal of Pharmaceutical Dosage Forms and Technology.2024; 16(2):127-2. doi: 10.52711/0975-4377.2024.00020   Available on: https://rjpdft.com/AbstractView.aspx?PID=2024-16-2-1


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