Author(s): Pushkar S. Chavan, Avish D. Maru, Majid S. Khan.

Email(s): pushkarchavan4614@gmail.com

DOI: 10.52711/0975-4377.2023.00042   

Address: Pushkar S. Chavan*, Avish D. Maru, Majid S. Khan.
Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal. Kalwan, Dist. Nashik, (MH) India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 4,     Year - 2023


ABSTRACT:
Mouth dissolving films (MDFs) of captopril were developed using natural polymers, including pectin, sodium alginate, and guar gum, in combination with the plasticizer polyethylene glycol 400 (PEG 400) and other ingredients like saliva stimulating agent, sweetener and super disintegrator etc. A total of nine formulations were prepared using different concentrations of the polymers by the solvent casting method. The objective of the study was to evaluate the suitability of these polymers and the effect of polymer concentration on the performance of the MDFs. The MDFs were evaluated based on various parameters, including folding endurance, dissolution, and disintegration studies. Among the different formulations, batch F4, which contained 50% (w/w) pectin as the polymer and 17% (w/w) PEG 400 as the plasticizer, exhibited satisfactory results. The folding endurance test indicated that batch F4 had good flexibility and strength, suggesting that it could withstand repeated folding without breaking or cracking. The in vitro dissolution study revealed that the MDFs of batch F4 exhibited rapid and complete drug release in 6 min, indicating their potential for enhanced drug delivery. The disintegration study further confirmed that the MDFs disintegrated within a short time, ensuring rapid disintegration and dissolution of the drug in the oral cavity.


Cite this article:
Pushkar S. Chavan, Avish D. Maru, Majid S. Khan.Formulation and Evaluation of Mouth Dissolving Films of Captopril by using Natural Polymers.Research Journal of Pharmaceutical Dosage Forms and Technology2023; 15(4):261-6. doi: 10.52711/0975-4377.2023.00042

Cite(Electronic):
Pushkar S. Chavan, Avish D. Maru, Majid S. Khan.Formulation and Evaluation of Mouth Dissolving Films of Captopril by using Natural Polymers.Research Journal of Pharmaceutical Dosage Forms and Technology2023; 15(4):261-6. doi: 10.52711/0975-4377.2023.00042   Available on: https://rjpdft.com/AbstractView.aspx?PID=2023-15-4-7


REFERENCES:
1.    DasariNirmala, SwapnaNandhini, M. Sudhakar. Design and evaluation of fast dissolving oral films of Zolpidem by solvent casting method. Asian J. Pharm. Res. 2016; 6(2): 67-71.
2.    Ahirwar Varsha, Khushwant S. Yadav, ShailendraBindaiya. Formulation Development and Evaluation of Fast Dissolving Films of OloptadineHCl. Asian Journal of Research in Pharmaceutical Sciences. 2021; 11(2):103-8
3.    Husain M, Agnihotri VV, Goyal SN, Agrawal YO. Development, optimization and characterization of hydrocolloid based mouth dissolving film of Telmisartan for the treatment of hypertension. Food Hydrocolloids for Health. 2022; 2:100064.
4.    Jasim IK, Abd-alhammid SN. Formulation and evaluation of mouth dissolving films of captopril. Pharmacie Globale. 2015; 6(4):1.
5.    Prateek Kumar, Rajneesh Kumar Gupta. Formulation and Characterization of Mouth Dissolving Films of Amlodipine using Natural Polymer. Research Journal of Pharmacy and Technology. 2022; 15(8):3651-5.
6.    Patil SB, Daswadkar S. A comprehensive review: natural polymers used for fast dissolving mouth film. International Journal of Pharmaceutical Sciences Review and Research. 2020; 65(3):14-21.
7.    Mishra R, Amin A. Manufacturing techniques of orally dissolving films. Pharmaceutical Technology. 2011; 35(1):70-3.
8.    Singh S. Preformulation Studies of Captopril for Novel Oral Drug Delivery System.
9.    Deepthi A, Reddy BV, Navaneetha K. Formulation and evaluation of fast dissolving oral films of zolmitriptan. American journal of advanced drug delivery. 2014; 2(2):153-63.
10.    Alhayali A, Vuddanda PR, Velaga S. Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva. Journal of Drug Delivery Science and Technology. 2019 Oct 1; 53:101122.
11.    Bala R, Pawar P, Khanna S, Arora S. Orally dissolving strips: A new approach to oral drug delivery system. International journal of pharmaceutical investigation. 2013; 3(2):67.
12.    Kulkarni AS, Deokule HA, Mane MS, Ghadge DM. Exploration of different polymers for use in the formulation of oral fast dissolving strips. J Curr Pharm Res. 2010; 2(1):33-5.
13.    SudhirMaddela, Buchi N. Nalluri. Development of Rizatriptan Mouth Dissolving Films: A Fast Absorbing Drug Delivery System for Effective Treatment of Migraine. Research J. Pharm. and Tech. 2019; 12(6): 2907-2916
14.    Pankaj A. Jadhav, Adhikrao V. Yadav. Polymeric Nanosuspension Loaded Oral Thin Films of Flurbiprofen: Design, Development and In Vitro Evaluation. Research J. Pharm. and Tech. 2020; 13(4): 1905-1910.
15.    D. Jayaprakash1, N. Swathi. Formulation and Characterization of Rosuvastatin Mouth dissolving films for the treatment of Hyperlipidemia. Research J.Pharm.andTech.2021;14(2):997-1002.
16.    S. Subramanian, P. Mani. Design, Development and Characterization of Flash release wafers containing Levocetrizine hydrochloride and Montelukast sodium. Research Journal of Pharmacy and Technology. 2022; 15(1):11-6.
17.    Hemant A. Deokule, Smita S. Pimple, Praveen D. Chaudhari, Ajit S. Kulkarni. Fabrication and Evaluation of Mouth Dissolving Strips of Metoclopramide Hydrochloride by Using Novel Film Former. Research Journal of Pharmacy and Technology. 2021; 14(10):5515-0.
18.    Pamula Reddy Bhavanam, Shaik Abdul Rahaman, M Mohan Varma. Tamarind Seed Polysaccharide Mouth Dissolving films for rapid drug Release in the treatment of Hypertension: In vitro Evaluation. Research Journal of Pharmacy and Technology. 2021; 14(5):2771-3.
19.    Kamma Keerthi Sai. Formulation Development and In vitro Evaluation of Memantine Hydrochloride Fast Dissolving Oral Films employing different grades of Hydroxy Propyl Methyl Cellulose. Research Journal of Pharmacy and Technology. 2022; 15(1):17-3.
20.    Adrover A, Pedacchia A, Petralito S, Spera R. In vitro dissolution testing of oral thin films: A comparison between USP 1, USP 2 apparatuses and a new millifluidic flow-through device. Chemical Engineering Research and Design. 2015; 95:173-8.
21.    Umar FarukSha A., PravinS. Formulation and Evaluation of Mouth Dissolving Films of Amlodipine Besylate by using Natural and Synthetic Polymers. Research Journal of Pharmacy and Technology. 2022; 15(11):5154-7.
22.    PoonamYadav, Parijat Pandey, Sonia Parashar, Neeta. Pectin as Natural Polymer: An overview. Research J. Pharm. and Tech. 2017; 10(4): 1225-1229.

Recomonded Articles:

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI:         Access: Open Access Read More

Author(s): Domendra Sahu, Shekhar Verma , Ravindra D. Dubey

DOI:         Access: Open Access Read More

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6         Access: Open Access Read More

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI:         Access: Open Access Read More

Author(s): R. K.V. Naga Sudha, V. Sai Kishore, CH. Venu Babu, E. Jitendranath

DOI: 10.5958/0975-4377.2015.00016.6         Access: Open Access Read More

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, Darsh Gautam, Parshuram Rai, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2017.00022.2         Access: Open Access Read More

Author(s): Suresh A. Marnoor

DOI:         Access: Open Access Read More

Author(s): Dilip M. Kumbhar, Kailas K. Mali, Remeth J. Dias, Vijay D. Havaldar, Vishwajeet S. Ghorpade, Nitin H. Salunkhe.

DOI: 10.5958/0975-4377.2016.00036.7         Access: Open Access Read More

Author(s): Doppalapudi Sandeep, A. P. Pratyusha, G. Sudheshna, K. Lakshmi prasanna, P. Sreekanth

DOI:         Access: Open Access Read More

Author(s): Debjit Bhowmik, Amrendra Singh , Praveen Khirwadkar, Nishi Shukla, Vikas Kumar Chaudhari

DOI: 10.5958/0975-4377.2016.00027.6         Access: Open Access Read More

Author(s): Omprasad Nayakal, Prajakta Patil, Mangesh Bhutkar, Dheeraj Randive, Somnath Bhinge

DOI: 10.5958/0975-4377.2018.00032.0         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00014.8         Access: Open Access Read More

Author(s): Malti Sao, Khomendra Kumar Sarwa, Amrendra Pratap Yadav, Seema Tandon, Moham Lal Kori

DOI: 10.5958/0975-4377.2019.00043.0         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags