Author(s): Sudhir Kathane, Shruti Rathore, Shashikant Chandrakar

Email(s): kathanesudhir@gmail.com

DOI: 10.52711/0975-4377.2024.00006   

Address: Sudhir Kathane1*, Shruti Rathore1, Shashikant Chandrakar2
1LCIT School of Pharmacy, Bilaspur, Chhattisgarh - 495220, India.
2Columbia Institute of Pharmacy, Raipur, Chhattisgarh - 493111, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 1,     Year - 2024


ABSTRACT:
Arthritis is most prevalent disorder and Indomethacin is choice of drug for arthritis. Oral route is most preferred route of drug administration and tablets are the more convenient dosage form. In present research natural polymers guar gum and xanthan gum were used to make sustained release tablet of Indomethacin. Indomethacin release from the tablets was studied in phosphate buffer pH 7.2. The drug release pattern of six different formulations in which xanthan gum and guar gum were used as a retarding material in different proportions was shown in table no. 6. The formulation F1 releases (75.20%) upto 12 hrs whereas the formulation F2 releases the drug (98.81%) in same time. The formulations F3, F4, F5 and F6 release 98.32%, 99.29%, 98.79% and 82.40% respectively. The dissolution pattern of both gums was similar i.e. with drug to polymer ratio (1:1). In present work F1 shows best sustained release upto 12 hrs in which Drug to Polymer ratio was 1:1:0 (Drug : Xanthan gum : Guar gum). In formulation F2 drug release was not sustained and complete release occurs in 12 hrs where the Drug to Polymer ratio was 1:1.67:0 (Drug: Xanthan gum : Guar gum). It was found that on the concentration of xanthan gum decreases the release rate of the drug also decreases. For sustain release there is not much role of Guar Gum reported. Indomethacin drug has been selected which has half-life 4.5 hrs. Hence the present work, an attempt has been made to provide sustained release drug delivery using polymers with Indomethacin as the model drug. Xanthan gum was best able to retard Indomethacin release mechanism even in the presence of a polymer. Polymer can be used to formulate successful sustained release Indomethacin matrix tablets that have desirable characteristics.


Cite this article:
Sudhir Kathane, Shruti Rathore, Shashikant Chandrakar. Formulation and Evaluation of Indomethacin Sustained Release Tablet by using Natural Polymers. Research Journal of Pharmaceutical Dosage Forms and Technology.2024; 16(1):35-1. doi: 10.52711/0975-4377.2024.00006

Cite(Electronic):
Sudhir Kathane, Shruti Rathore, Shashikant Chandrakar. Formulation and Evaluation of Indomethacin Sustained Release Tablet by using Natural Polymers. Research Journal of Pharmaceutical Dosage Forms and Technology.2024; 16(1):35-1. doi: 10.52711/0975-4377.2024.00006   Available on: https://rjpdft.com/AbstractView.aspx?PID=2024-16-1-6


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