The present study was under taken to develop oral modified release formulations for Losartan Potassium, an angiotensin-ii antagonist for the treatment of Hypertension. The tablets were prepared by wet granulation technique by using natural (Guar gum, Xanthan, Gum karaya, Gum kondagogu, Olibanum) and modified [CMGG (Carboxy methylated guar gum), CMGG-I (Carboxy methylated guar gum-Iodine), BG-C (Borax Guar gum- Cross linked), BG-F (Borax Guar gum- Films)] gums as release retardant polymers. The evaluation involves 3 stages i.,e. pre-compression, post compression parameters and in-vitro release kinetics assessment of tablets. The USP-II paddle method was selected to perform the dissolution test and 900ml of water was used as dissolution medium at 100rpm at 370C ± 0.5. The release kinetics was analyzed. All the formulations followed Peppa’s release mechanism. When the release data was plotted into korsmeyer-Peppas equation (log cumulative % of drug release Vs log time), it was observed that formulations F1, F4, F5 (formulated with selected gums), F6 (formulated with modified gums)followed Anamalous (non- Fickian) type of mechanism whereas the formulations F2, F3 (formulated with selected gums) followed case II mechanism and formulations F7 to F9 (formulated with modified gums) followed Anamolous(Fickian) type of mechanisms. The in-vitro release studies revealed that the formulation F1 can be taken as ideal or optimized formulation for modified release formulations as it fulfills all the requirements.
Cite this article:
T. E. Gopala Krishna Murthy, A. Lakshmi Madalasa. Design and Development of Oral Modified Release Formulations for Losartan Potassium with Natural and Modified Gums. Res. J. Pharma. Dosage Forms and Tech.2018; 10(3):149-156. doi: 10.5958/0975-4377.2018.00023.X