Author(s): Shilpa Jagtap, Smrutidevi Sonavane, Shrikrishna Baokar, Vinod Pawar, Patil R. N.

Email(s): Email ID Not Available

DOI: Not Available

Address: Shilpa Jagtap1, Smrutidevi Sonavane1, Shrikrishna Baokar1*, Vinod Pawar2, Patil R. N.1
1Department of Pharmaceutical Chemistry, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk), Tal- Baramati, Dist -Pune, Maharashtra, India – 413115.
2Department of Pharmacology, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk), Tal- Baramati, Dist -Pune, Maharashtra, India – 413115.
*Corresponding Author:

Published In:   Volume - 5,      Issue - 5,     Year - 2013


ABSTRACT:
A rapid dissolution method was developed for the evaluation of Roxithromycin tablets and the determination of Roxithromycin content was done by UV-spectrophotometer. The proposed method comprises the measurement absorbance of standard concentrations of Roxithromycin in the pH 6.0 phosphate buffer solution against wavelength maximum [?max] of 205 nm. Beer's Law limits were obeyed in the concentration range of 1µg/ml – 10µg/ml. The linear regression coefficient was estimated to be 0.999 and the linear regression equation obtained was y=0.0954x-0.0014. The solutions were stable for more than 12 hours. The method has been extended for the determination of Roxithromycin content in tablets after the dissolution for 60 minutes at 50 rpm using USP Apparatus II [Paddle apparatus] under experimental conditions. The unknown concentration of Roxithromycin in the solution was estimated from the standard curve and it was found to be within the range of the labeled claim. The relative standard deviation of six replicate solutions was determined to be 0.55. No interference of excipient and coating material was found in this method. This method is economical, precise and accurate. Hence, this method can be employed for the routine evaluation of Roxithromycin tablets by dissolution and dissolution profile by using pH 6.0 phosphate buffer as a medium.


Cite this article:
Shilpa Jagtap, Smrutidevi Sonavane, Shrikrishna Baokar, Vinod Pawar, Patil R. N. In Vitro New Dissolution Method for the Evaluation of Roxithromycin using pH 6.0 Phosphate Buffer and Determination of its Content by Validated UV Spectrophotometric Method. Research J. Pharma. Dosage Forms and Tech. 2013; 5(5): 277-281.

Cite(Electronic):
Shilpa Jagtap, Smrutidevi Sonavane, Shrikrishna Baokar, Vinod Pawar, Patil R. N. In Vitro New Dissolution Method for the Evaluation of Roxithromycin using pH 6.0 Phosphate Buffer and Determination of its Content by Validated UV Spectrophotometric Method. Research J. Pharma. Dosage Forms and Tech. 2013; 5(5): 277-281.   Available on: https://rjpdft.com/AbstractView.aspx?PID=2013-5-5-7


Recomonded Articles:

Author(s): Hapse S.A., Bhagat B.V., Wagh V.S. , Kadaskar P.T.

DOI:         Access: Open Access Read More

Author(s): Domendra Sahu, Shekhar Verma , Ravindra D. Dubey

DOI:         Access: Open Access Read More

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6         Access: Open Access Read More

Author(s): Soham Shukla, Vikram Pandya, Praful Bhardia, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Deependra Jain

DOI:         Access: Open Access Read More

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI:         Access: Open Access Read More

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Author(s): R. K.V. Naga Sudha, V. Sai Kishore, CH. Venu Babu, E. Jitendranath

DOI: 10.5958/0975-4377.2015.00016.6         Access: Open Access Read More

Author(s): B. Thangabalan, Ch. Sandhya, N. Sunitha, S. Manohar Babu

DOI:         Access: Open Access Read More

Author(s): Malti Sao, Khomendra Kumar Sarwa, Amrendra Pratap Yadav, Seema Tandon, Moham Lal Kori

DOI: 10.5958/0975-4377.2019.00043.0         Access: Open Access Read More

Author(s): Sayad Basha.K, Sheema Nafees. S, Nethravani. G, Thirumalesh Naik S.B

DOI: 10.5958/0975-4377.2016.00015.X         Access: Open Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, Darsh Gautam, Parshuram Rai, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2017.00022.2         Access: Open Access Read More

Author(s): Akelesh T., R. Ramya, Venkatesh. P., Divya Jacob , R. Venkatnarayanan

DOI:         Access: Open Access Read More

Author(s): Doppalapudi Sandeep, A. P. Pratyusha, G. Sudheshna, K. Lakshmi prasanna, P. Sreekanth

DOI:         Access: Open Access Read More

Author(s): B. Siddartha, I. Sudheer Babu, C. Parthiban, C. Madhavi

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags