A review Superdisintegrants: A Recent Investigation and Current Approach

Himanshu Deshmkh; Chandrashekhara S.; Nagesh C; Amol Murade; Shridhar Usgaunkar

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

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A review Superdisintegrants: A Recent Investigation and Current Approach

Author(s): Himanshu Deshmkh, Chandrashekhara S., Nagesh C, Amol Murade, Shridhar Usgaunkar

Email(s): Shekhar_bio@yahoo.co.in

DOI: Not Available

Address: Himanshu Deshmkh, Chandrashekhara S.*, Nagesh C, Amol Murade, Shridhar Usgaunkar
Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karnataka.
*Corresponding Author

Published In: Volume - 4, Issue - 2, Year - 2012

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ABSTRACT:
The desire of improved palatability in orally administered products has prompted the development of numerous formulations with improved performance and acceptability. Orally disintegrating tablets are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. Superdisintegrants are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhances drug dissolution rate. Disintegrants are substances or mixture of substances added the drug formulation that facilitates the breakup or disintegration of tablet or capsule content into smaller particles that dissolve more rapidly than in the absence of disintegrants. In recent years, several newer agents have been developed known as Superdisintegrants. Diverse categories of Superdisintegrants such as synthetic, semi-synthetic, natural and co-processed blends etc. have been employed to develop effectual mouth dissolving tablets and to overcome the limitations of conventional tablet dosage form. Superdisintegrants are generally used at a low level in the solid dosage form, typically 1- 10 % by weight relative to the total weight of the dosage unit. The present study comprises the various kinds of Superdisintegrants which are being used in the formulation to provide the safer, effective drug delivery with patient's compliance.

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Cite this article:
Himanshu Deshmkh, Chandrashekhara S., Nagesh C, Amol Murade, Shridhar Usgaunkar . A review Superdisintegrants: A Recent Investigation and Current Approach. Research J. Pharma. Dosage Forms and Tech. 2012; 4(2): 86-92 .

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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

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DOI: 10.5958/0975-4377