Author(s): R. Sakthikumar, R. Lathaeswari, R. Senthamarai, T.N.K. Suriyaprakash, A. Anithaa

Email(s): sakthikumar2k4@yahoo.com

DOI: Not Available

Address: R. Sakthikumar*, R. Lathaeswari, R. Senthamarai, T.N.K. Suriyaprakash and A. Anithaa
Department of Pharmaceutics, Periyar College of Pharmaceutical Sciences, K. Sathanoor Main Road, Tiruchirapalli-620021
*Corresponding Author

Published In:   Volume - 2,      Issue - 6,     Year - 2010


ABSTRACT:
The objective of the present study is to formulate once daily controlled porosity osmotic tablet of Propanolol HCl for the treatment of Hypertension and to reduce the pill burden by avoiding dosing frequency. Controlled porosity osmotic tablets have an advantage of avoiding cost and labor. Six batches (F1-F6) of osmotic tablets were made with Mannitol, KCl and NaCl as osmotic agent by wet granulation technique. The granules were evaluated for precompression properties. The granules were compressed into tablet using Rotary tablet compression machine. The tablets were coated with Ethyl Cellulose (F1E-F6E) and Cellulose Acetate (F1C-F6C) as coating polymer i.e. semipermeable membrane. The tablets were subjected to evaluation parameters like weight variation, hardness, friability, % weight increase for coated tablet and in-vitro dissolution using USP Type I apparatus. All batches compiles with pharmacoepial standards. Among the twelve batches F5C showed sustained release over a period of 20 hrs with 80.59% drug release. The best formulation was subjected to stability studies for 3 months 45°C and 70% RH.


Cite this article:
R. Sakthikumar, R. Lathaeswari, R. Senthamarai, T.N.K. Suriyaprakash, A. Anithaa. Formulation and Evaluation of Propanolol HCl Controlled Porosity Osmotically Controlled Tablet. Research J. Pharma. Dosage Forms and Tech. 2010; 2(6): 378-380.


Recomonded Articles:

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI:         Access: Open Access Read More

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Author(s): Dilip M. Kumbhar, Kailas K. Mali, Remeth J. Dias, Vijay D. Havaldar, Vishwajeet S. Ghorpade, Nitin H. Salunkhe.

DOI: 10.5958/0975-4377.2016.00036.7         Access: Open Access Read More

Author(s): Debjit Bhowmik, Amrendra Singh , Praveen Khirwadkar, Nishi Shukla, Vikas Kumar Chaudhari

DOI: 10.5958/0975-4377.2016.00027.6         Access: Open Access Read More

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI:         Access: Open Access Read More

Author(s): Sawant VA, Jayprabha P, Shende VS, Borkar SN, Wakale VS, Deore SR, Dame GY, Barve AO, Chatap VK

DOI:         Access: Open Access Read More

Author(s): V Ganesan, Nilesh P Tekade, Nitin S Bhajipale, Durgesh R Dewade, Raju R Thenge

DOI:         Access: Open Access Read More

Author(s): Swati Rawat, Shradha Sangali, Akhilesh Gupta

DOI: 10.5958/0975-4377.2018.00001.0         Access: Open Access Read More

Author(s): Suresh A. Marnoor

DOI:         Access: Open Access Read More

Author(s): Sachin N. Kothawade, Ashwini Ishware, Priyanka Darekar, Amit S. Lunkad

DOI:         Access: Open Access Read More

Author(s): Doppalapudi Sandeep, A. P. Pratyusha, G. Sudheshna, K. Lakshmi prasanna, P. Sreekanth

DOI:         Access: Open Access Read More

Author(s): Amit K. Jain, Rajput Rammulrajsinh, Pradeep Agrawal, Kinal patel

DOI:         Access: Open Access Read More

Author(s): Bhoyar PK, Biyani DM, Shahare HV, Ikhar PK,Borkar VS

DOI:         Access: Open Access Read More

Author(s): Chinmaya Keshari Sahoo, Surepalli Ram Mohan Rao, Muvvala Sudhakar

DOI: 10.5958/0975-4377.2017.00020.9         Access: Open Access Read More

Author(s): Sonia Singh, Umesh D. Shivhare, S. N. Sakarkar

DOI:         Access: Open Access Read More

Author(s): Susmitha. A, Narendra Babu. K, Imran Khan Pathan, Ishwarya. K

DOI:         Access: Open Access Read More

Author(s): Prasanta Kumar Choudhury, Padala Narasimha Murthy, Suvakanta Dash, Rana Mazumder, Dhruba Sankar Goswami

DOI:         Access: Open Access Read More

Author(s): VASEEHA BANU TS, SUKHEN SOM

DOI:         Access: Open Access Read More

Author(s): K. Vyshnavi, Madhuri Bhashetty, Namitha Swain, M. Venkataswamy, Alluri Ramesh

DOI: 10.5958/0975-4377.2017.00009.X         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags