Design Development of Liquisolid Compacts of Atorvastatin Calcium

A. Navya Krishna; Y. Deepthi; S. Aruna; T E G K Murthy

doi:DOI: 10.5958/0975-4377.2015.00013.0

Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)

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Design Development of Liquisolid Compacts of Atorvastatin Calcium

Author(s): A. Navya Krishna, Y. Deepthi, S. Aruna, T E G K Murthy

Email(s): bcpbtl@sancharnet.in

DOI: DOI: 10.5958/0975-4377.2015.00013.0

Address: A. Navya Krishna*, Y. Deepthi, S. Aruna, T E G K Murthy
Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), A.P.-522101 India,
*Corresponding Author

Published In: Volume - 7, Issue - 2, Year - 2015

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ABSTRACT:
The present work is to formulate and evaluate liquisolid compacts of Atorvastatin calcium. Atorvastatin calcium is an anti hyperlipedmic drug belongs to class of statins. The bioavailability is 14% due to dissolution rate limitation and its biological half life is 14 hours. The solubility of Atorvastatin was enhanced by liquid solid compact technology. So the aim of this work is to increase the solubility and in-vitro dissolution of practically insoluble drug Atorvastatin, liquisolid tablet consists of lactose (flowlac), cab-o-sill and PG as liquid vehicle. The prepared formulations were evaluated for drug content, weight variation, hardness, friability, disintegration, dissolution. The better drug release was observed from the F8 formulation (1:5) containing (flowlac) Atorvastatin 20 mg, carrier 505.65 mg, coating material 10mg, and super disintegrating and lubricants 11.64, 23.45 were added. The selected formulation was evaluated for stability studies.

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Cite this article:
A. Navya Krishna, Y. Deepthi, S. Aruna, T E G K Murthy. Design Development of Liquisolid Compacts of Atorvastatin Calcium. Res. J. Pharm. Dosage Form. & Tech. 7(2): April-June, 2015; Page 93-97. doi: DOI: 10.5958/0975-4377.2015.00013.0

Cite(Electronic):
A. Navya Krishna, Y. Deepthi, S. Aruna, T E G K Murthy. Design Development of Liquisolid Compacts of Atorvastatin Calcium. Res. J. Pharm. Dosage Form. & Tech. 7(2): April-June, 2015; Page 93-97. doi: DOI: 10.5958/0975-4377.2015.00013.0 Available on: https://rjpdft.com/AbstractView.aspx?PID=2015-7-2-1

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DOI: 10.5958/0975-4377