Transdermal patches are designed to slowly deliver the drug substance(s) through the intact skin; resulting in a prolonged and adequately constant systemic absorption rate after passing through the skin barriers, and it avoid first pass effect. Through a diffusion process, the drug enters the bloodstream directly though the skin. For this studies design the transdermal drug delivery system of Ivabradine hydrochloride with ERS100 and Hydroxy propyl methyl cellulose polymer in various concentrations. Propylene glycol was used as a plasticizer and dimethyl sulphoxides used as permeation enhancer. Characterization of transdermal patch is use to check it’s quality, thickness, weight of patch, uniformity and in vitro permeation studies. The market for transdermal products has been in a significant upward trend that is likely to continue for the foreseeable future. It was observed that the formulation containing ERS100: HPMC K100M (4:6) showed ideal higuchi release kinetics. On the basis of in vitro drug release through skin permeation performance, Formulation A2 was found to be better than other formulations and it was selected as the optimized formulation. An increasing number of TDD products continue to deliver real therapeutic benefit to patients around the world.
Cite this article:
Samir Gaur, Ashish Kumar Sharma. Development and Evaluation of Transdermal Drug Delivery System of Ivabradine Hydrochlride. Research J. Pharma. Dosage Forms and Tech. 2013; 5(4): 237-241.