Development and Characterization of a Stable Suspension of Rifampicin and Isoniazid

AM Avachat; SB Bhise

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

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Development and Characterization of a Stable Suspension of Rifampicin and Isoniazid

Author(s): AM Avachat, SB Bhise

Email(s): prof_avachat@yahoo.com

DOI: Not Available

Address: AM Avachat1* and SB Bhise2
1Department of Pharmaceutics, Sinhgad College of Pharmacy, Pune, 411 041, Maharashtra, India
2Govt. College of Pharmacy, Karad, 415124, Maharashtra, India
*Corresponding Author

Published In: Volume - 1, Issue - 3, Year - 2009

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ABSTRACT:
Rifampicin (RMP) and Isoniazid (INH) are highly unstable in liquid dosage form and there is no liquid product available. A novel concept of formulating a suspension of RMP and INH for pediatric and geriatric application has been tried. The reconstitutable dry syrup which can be reconstituted by using a special vehicle has shown very good stability at 2-80C and at 250C for more than 1 month and 14 days respectively using a stability indicating HPLC method. The in vitro dissolution studies have revealed no adverse impact of special vehicle on dissolution. Thus this combination product could prove to be a major boost for the market need for pediatric patients.

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Cite this article:
AM Avachat, SB Bhise. Development and Characterization of a Stable Suspension of Rifampicin and Isoniazid. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):213-216.

Cite(Electronic):
AM Avachat, SB Bhise. Development and Characterization of a Stable Suspension of Rifampicin and Isoniazid. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):213-216. Available on: https://rjpdft.com/AbstractView.aspx?PID=2009-1-3-10

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DOI: 10.5958/0975-4377