Author(s): Nipanikar Madhuri, Shrikrishna Baokar, Undare Santosh, Patil R. N.

Email(s): Email ID Not Available

DOI: 10.5958/0975-4377.2016.00010.0   

Address: Nipanikar Madhuri1, Shrikrishna Baokar1*, Undare Santosh2, Patil R. N.1
1Department of Pharmaceutical Analysis, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk), Tal- Baramati, Dist- Pune, Maharashtra, India 413115
2PG Department of Chemistry, Marathwada Shikshan Prasarak Mandal’s Balbhim Arts, Science and Commerce College, Beed, Maharashtra, India 431112.

Published In:   Volume - 8,      Issue - 1,     Year - 2016


ABSTRACT:
Glipizide (GPZ) is chemically 1cyclohexyl3 [[p[2(5methylpyrazinecarboxamido)ethyl]phenyl] sulfonyl]urea, used in the treatment of type II diabetes mellitus. The drug is commercially available as tablets for oral administration. In the present work three simple, economical, precise and accurate UV spectrophotometrically methods have been developed for the estimation of GPZ in bulk and pharmaceutical formulation. The present method has been developed in distil 0.1 N NaOH which makes it economic and reproducible. An absorption maximum was obtained at 227 nm. The method is validated using ICH Q2R1 guideline for various parameters like precision, accuracy, etc. Drug follows linearity in concentration range 1-10 µg/ml with correlation coefficient value (r2) 0.999. The accuracy study was performed by recovery checking at three different concentrations i.e., 80%, 100% and 120 %. The % recovery was found well in limit. The precision of the method was studied as an intra-day (% R.S.D. = 0.44 %) and for inter-day (% R.S.D. = 0.22 %) variations. The % R.S.D. value less than 2 indicate that the method is precise. The proposed method is a cost-effective quality-control tool for routine analysis of GPZ in pharmaceutical dosage form.


Cite this article:
Nipanikar Madhuri, Shrikrishna Baokar, Undare Santosh, Patil R. N.. Ultraviolet Spectrophotometric Method for Determination of Glipizide in Bulk and Tablet Dosage Formulation. Res. J. Pharm. Dosage Form. & Tech. 8(1): Jan.-Mar. 2016; Page 05-08. doi: 10.5958/0975-4377.2016.00010.0


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DOI: 10.5958/0975-4377 


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