Author(s): Mukul Rajgure, Pallavi Wadaskar, Komal Nirale

Email(s): vedanshumlv56@gmail.com

DOI: 10.52711/0975-4377.2023.00023   

Address: Mukul Rajgure1*, Pallavi Wadaskar2, Komal Nirale3
1Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati, Maharashtra - 444602.
2Department of Pharmaceutics, Sharadchandra Pawar College of Pharmacy, Dumbarwadi, Maharashtra - 412409.
3Department of Pharmaceutics, Sharadchandra Pawar College of Pharmacy, Dumbarwadi, Maharashtra - 412409.
*Corresponding Author

Published In:   Volume - 15,      Issue - 2,     Year - 2023


ABSTRACT:
Gels formed in situ have quickly emerged as one of the most widely used and easily accessible methods. These systems have a number of advantages, including simple production, ease of use, enhanced adherence, and patient comfort by limiting the amount of times drugs need to be administered due to its one-of-a-kind characteristics, which include a sol-to-gel transition. The precursor is subjected to hydrolysis as well as polymerization or condensation in the ‘sol-gel' process, which ultimately results in the production of a colloidal suspension or solution. In spite of the fact that these in situ gelling systems can be administered in solution form, the gelation process takes place at the achievement site. Recent years have seen the development of in situ gelling systems for liposomes, microspheres, nanoemulsions, nanospheres, and other similar structures by a few researchers. This review primarily concentrated on the introduction, followed by a discussion of the benefits, drawbacks, different types of polymers, and desirable qualities for the preparation of in situ gels.


Cite this article:
Mukul Rajgure, Pallavi Wadaskar, Komal Nirale. A Review on the many different types of Polymers that are Utilized in the Production of in Situ Gels. Research Journal of Pharmaceutical Dosage Forms and Technology.2023; 15(2):138-2. doi: 10.52711/0975-4377.2023.00023

Cite(Electronic):
Mukul Rajgure, Pallavi Wadaskar, Komal Nirale. A Review on the many different types of Polymers that are Utilized in the Production of in Situ Gels. Research Journal of Pharmaceutical Dosage Forms and Technology.2023; 15(2):138-2. doi: 10.52711/0975-4377.2023.00023   Available on: https://rjpdft.com/AbstractView.aspx?PID=2023-15-2-11


REFERENCES:
1.    Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019 Dec 30; 12(12):5972-6.
2.    HB N, Bakliwal S, Pawar S. In-situ gel: new trends in controlled and sustained drug delivery system. International Journal of PharmTech Research. 2010 Apr; 2(2):1398-408.
3.    Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019; 8(8):624-9.
4.    Bai B, Leng J, Wei M. A comprehensive review of in-situ polymer gel simulation for conformance control. Petroleum Science. 2021 Sep 29.
5.    Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31; 13(3):4942-51.
6.    Majeed A, Khan NA. Ocular in situ gel: An overview. Journal of Drug Delivery and Therapeutics. 2019 Jan 15; 9(1):337-47.
7.    Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020; 6(2):94-100.
8.    Bai B, Zhou J, Yin M. A comprehensive review of polyacrylamide polymer gels for conformance control. Petroleum exploration and development. 2015 Aug 1; 42(4):525-32.
9.    Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31; 13(1):4745-52.
10.    Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co-Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 1; 14(3):1535-41.
11.    Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian journal of pharmaceutical education and research. 2021 Jan 1; 55(1):86-94.
12.    Mohanty D, Bakshi V, Simharaju N, Haque MA, Sahoo CK. A review on in situ gel: a novel drug delivery system. Int. J. Pharm. Sci. Rev. Res. 2018; 50(1):175-81.
13.    Sun Q, Wang S, Ma Y, Zhou Y, Song D, Zhang H, Shi X, Li C, Zhang L. Fumaronitrile-fixed in-situ gel polymer electrolyte balancing high safety and superior electrochemical performance for Li metal batteries. Energy Storage Materials. 2022 Jan 1; 44:537-46.
14.    Vijaya Rani KR, Rajan S, Bhupathyraaj M, Priya RK, Halligudi N, Al-Ghazali MA, Sridhar SB, Shareef J, Thomas S, Desai SM, Pol PD. The effect of polymers on drug release kinetics in nanoemulsion in situ gel formulation. Polymers. 2022 Jan 21; 14(3):427.
15.    Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31; 14(10):5345-0.
16.    Burange PJ, Tawar MG, Bairagi RA, Malviya VR, Sahu VK, Shewatkar SN, Sawarkar RA, Mamurkar RR. Synthesis of silver nanoparticles by using Aloe vera and Thuja orientalis leaves extract and their biological activity: a comprehensive review. Bulletin of the National Research Centre. 2021 Dec; 45(1):1-3.
17.    Xu D, Su J, Jin J, Sun C, Ruan Y, Chen C, Wen Z. In situ generated fireproof gel polymer electrolyte with Li6. 4Ga0. 2La3Zr2O12 as initiator and ion‐conductive filler. Advanced Energy Materials. 2019 Jul; 9(25):1900611.
18.    Malviya V. Design and Characterization of Thermosensitive Mucoadhesive Nasal Gel for Meclizine Hydrochloride. International Journal of Pharmaceutical Sciences and Nanotechnology. 2022 Feb 28; 15(1):5782-93.
19.    Chen H, Lang Q, Bi Z, Miao X, Li Y, Pu J. Impregnation of poplar wood (Populus euramericana) with methylolurea and sodium silicate sol and induction of in-situ gel polymerization by heating. Holzforschung. 2014 Jan 1; 68(1):45-52.
20.    Malviya V, Burange P, Thakur Y, Tawar M. Enhancement of Solubility and Dissolution Rate of Atazanavir Sulfate by Nanocrystallization. Indian Journal of Pharmaceutical Education and Research. 2021 Jul 1; 55(3):S672-80.
21.    Malviya, Vedanshu, Mukund Tawar, Prashant Burange, and Rahul Jodh. "A Brief Review on Resveratrol." (2022): 157-162.
22.    Malviya V, Arya A, Burange P, Gajbhiye K, Rathod G, Tawar M. To Evaluate the Cardioprotective effect of Hydroalcoholic Extract of Matricaria chamomilla Linn in Isoproterenol Induced Myocardial Infarction in Wistar Rats. Research Journal of Pharmacy and Technology. 2022 Sep 28; 15(9):3887-92.
23.    Parris MD, MacKay BA, Rathke JW, Klingler RJ, Gerald RE. Influence of pressure on boron cross-linked polymer gels. Macromolecules. 2008 Nov 11; 41(21):8181-6.
24.    Peterson AM, Jensen RE, Palmese GR. Reversibly cross-linked polymer gels as healing agents for epoxy− amine thermosets. ACS applied materials & interfaces. 2009 May 27; 1(5):992-5.
25.    Panyukov S, Rabin Y. Statistical physics of polymer gels. Physics Reports. 1996 May 1; 269(1-2):1-31.
26.    Al-Muntasheri GA, Hussein IA, Nasr-El-Din HA, Amin MB. Viscoelastic properties of a high temperature cross-linked water shut-off polymeric gel. Journal of Petroleum Science and Engineering. 2007 Jan 1; 55(1-2):56-66.
27.    Li ZY, Zhang Y, Zhang CW, Chen LJ, Wang C, Tan H, Yu Y, Li X, Yang HB. Cross-linked supramolecular polymer gels constructed from discrete multi-pillar [5] arene metallacycles and their multiple stimuli-responsive behavior. Journal of the American Chemical Society. 2014 Jun 18; 136(24):8577-89.
28.    Bhandwalkar MJ, Avachat AM. Thermoreversible nasal in situ gel of venlafaxine hydrochloride: formulation, characterization, and pharmacodynamic evaluation. Aaps Pharmscitech. 2013 Mar; 14(1):101-10.
29.    Abou Youssef NA, Kassem AA, Farid RM, Ismail FA, Magda Abd Elsamea EM, Boraie NA. A novel nasal almotriptan loaded solid lipid nanoparticles in mucoadhesive in situ gel formulation for brain targeting: preparation, characterization and in vivo evaluation. International journal of pharmaceutics. 2018 Sep 5; 548(1):609-24.
30.    Barakat SS, Nasr M, Ahmed RF, Badawy SS, Mansour S. Intranasally administered in situ gelling nanocomposite system of dimenhydrinate: preparation, characterization and pharmacodynamic applicability in chemotherapy induced emesis model. Scientific Reports. 2017 Aug 30; 7(1):1-3.

Recomonded Articles:

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI:         Access: Open Access Read More

Author(s): Domendra Sahu, Shekhar Verma , Ravindra D. Dubey

DOI:         Access: Open Access Read More

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Isha Shah, Nensi Raytthatha, Jigar Vyas, Umesh Upadhyay

DOI: 10.52711/0975-4377.2021.00039         Access: Open Access Read More

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI:         Access: Open Access Read More

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Author(s): Swati Talokar, Rohan R Vakhariya, A.R Dhole

DOI: 10.5958/0975-4377.2017.00005.2         Access: Open Access Read More

Author(s): Varsha R. Sandhan, S.B. Gondkar, R. B. Saudagar

DOI:         Access: Open Access Read More

Author(s): Suresh A. Marnoor

DOI:         Access: Open Access Read More

Author(s): Swati S Talokar, Rohan R Vakhariya

DOI: 10.5958/0975-4377.2017.00001.5         Access: Open Access Read More

Author(s): Doppalapudi Sandeep, A. P. Pratyusha, G. Sudheshna, K. Lakshmi prasanna, P. Sreekanth

DOI:         Access: Open Access Read More

Author(s): Dilip M. Kumbhar, Kailas K. Mali, Remeth J. Dias, Vijay D. Havaldar, Vishwajeet S. Ghorpade, Nitin H. Salunkhe.

DOI: 10.5958/0975-4377.2016.00036.7         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags