Author(s): Sheeba FR, Amar Sahani, Yogesh DB



Address: Sheeba FR1*, Amar Sahani1, Yogesh DB2
1Mallige College of Pharmacy, Bengaluru 560090, Karnataka, India.
2Subtle Pharmaceutical Private limited, Bengaluru 560058, Karnataka, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 4,     Year - 2022

Aim: This study is aimed to prepare floating matrix Domperidone Maleate tablets by using natural polymers. Materials and Methods: Domperidone maleate was formulated as floating matrix tablets to increase the gastric residence time. Natural polymers like xanthan gum, tragacanth, sodium alginate along with sodium bicarbonate, citric acid and HPMC were used to increase the buoyancy time and decrease the floating lag time. The compressed tablets were evaluated for various parameters like friability, hardness, uniformity of weight, uniformity of drug content, swelling index, bouncy time and in-vitro drug release. Results: The evaluated parameters were in compliance with the pharmacopoeial limits. The most successful formulation was F2, containing xanthan gum as polymer. The drug release was extended up to 10 h which was close to that of theoretical release profile. Mathematical modelling of in-vitro dissolution data indicated the best-fit release kinetics was achieved with Zero order model with R2 values of 0.99. Conclusion: The prepared sustained-release floating tablets of domperidone maleate could perform therapeutically better than that of conventional sustained release tablets with improved efficacy and better patient compliance.

Cite this article:
Sheeba FR, Amar Sahani, Yogesh DB. Natural Polymer Based Floating Matrix Tablets of Domperidone. Research Journal of Pharmaceutical Dosage Forms and Technology. 2022; 14(4):269-5. doi: 10.52711/0975-4377.2022.00044

Sheeba FR, Amar Sahani, Yogesh DB. Natural Polymer Based Floating Matrix Tablets of Domperidone. Research Journal of Pharmaceutical Dosage Forms and Technology. 2022; 14(4):269-5. doi: 10.52711/0975-4377.2022.00044   Available on:

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DOI: 10.5958/0975-4377 

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