Author(s): Vani Mamillapalli, Mounika Katamaneni, Vamsi Meghana Tiyyagura, Praneetha Kanajam, Aslesha Padmavathi Namagiri, Haripriya Thondepu, Bhavani Appikatla, Bhavana Devangam, Padmalatha Khantamneni

Email(s): vanimamillapalli@yahoo.co.in

DOI: 10.5958/0975-4377.2020.00024.5   

Address: Vani Mamillapalli1*, Mounika Katamaneni1, Vamsi Meghana Tiyyagura1, Praneetha Kanajam1, Aslesha Padmavathi Namagiri1, Haripriya Thondepu1, Bhavani Appikatla1, Bhavana Devangam1, Padmalatha Khantamneni2
1Department of Pharmacognosy and Phytochemistry, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu-521108, Vijayawada, Krishna (Dt.), Andhra Pradesh, India.
2Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu-521108, Vijayawada, Krishna (Dt.), Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 3,     Year - 2020


ABSTRACT:
The present study aims at formulation of polyherbal vanishing cream and face wash, determination of total flavonoid content of herbs used, evaluation of formulations for various physical parameters followed by antibacterial and antifungal activities. The problems of premature ageing, damage due to irradiation, loss of pigmentation, moisture, nourishment, and acne can be solved by supplementation of health benefits provided by selected multiple herbs in the formulations. The use of polyherbal vanishing cream and face wash promotes skin health and beauty. The selected nine herbs in vanishing cream and eleven herbs in face wash formulations contain good amount of flavonoids capable of protecting skin against damage. The total flavonoid content of herbs used was determined, followed by evaluation of various physical parameters such as pH, viscosity, spreadability and compared with marketed formulations. Further, the formulations were tested against gram positive S.aureus, gram negative E.coli, and fungus C.albicans which are common associates of acne and cosmetic appliances. The results indicated that both the formulations displayed better antibacterial and antifungal activities than marketed formulations. Therefore, they can be tested further for their performance and quality control parameters.


Cite this article:
Vani Mamillapalli, Mounika Katamaneni, Vamsi Meghana Tiyyagura, Praneetha Kanajam, Aslesha Padmavathi Namagiri, Haripriya Thondepu, Bhavani Appikatla, Bhavana Devangam, Padmalatha Khantamneni. Formulation, Phytochemical, Physical, Biological Evaluation of Polyherbal Vanishing Cream, and Facewash. Res. J. Pharma. Dosage Forms and Tech.2020; 12(3): 139-149. doi: 10.5958/0975-4377.2020.00024.5


REFERENCES:
1. Tzellos TG, Klagas I, Vahtsevanos K, Triaridis S, Printza A, Kyrgidis A, et al. Extrinsic ageing in the human skin is associated with alterations in the expression of hyaluronic acid and its metabolizing enzymes. Exp Dermatol. 2009; 18: 1028–35.
2. John D, Stuart J, Alexandra A, Timothy S. UV Radiation and the Skin. Int J Mol Sci. 2013; 14(6): 12222–12248.
3. Ristow M,  Zarse K, Oberbach A, Klöting N, Birringer M, Kiehntopf M, et al. Antioxidants prevent health-promoting effects of physical exercise  in  humans. Proc Natl Acad Sci U S A. 2009; 106:86: 65–70.
4. Ristow M, Schmeisser S. Extending life  span  by  increasing  oxidative  stress. Free Radic Biol Med. 2011; 51: 327–36.
5. Cosgrove MC, Franco OH, Granger SP, Murray PG, Mayes AE. Dietary nutrient intakes and skin-aging appearance among middle-aged American women. Am J Clin Nutr 2007; 86: 1225–31.
6. Gollnick HP, Zouboulis CC, Akamatsu H, Kurokawa I, Schulte A. Pathogenesis and pathognesis-related treatment of acne. J Dermatol. 1991; 18: 489–99.
7. Corazza M1, Carla E, Rossi MR, Pedna MF, Virgili A. Face and body sponges:beauty aids or potential microbiological reservoir. Eur J Dermatol. 2003; 13 (6):571-3
8. Hacker J, Blumoehler G, Muhldofer I, Tschape H. Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evaluation. Mol Microbiol. 1997: 1089-1097.
9. Easmon CSF, Adlam C. Staphylococci and staphylococcal infections. Vol I and II, Academic Press, London,1983.
10. Albuquerque P  and Casdevall A. Quorum sensing in fungi-A review. Med Mycol. 2012; 50: 337-345.
11. Ashwini SD, Somishwar SK, Shweta S S. Formulation and Evaluation of Vanishing Herbal Cream of Crude Drugs. A J Ethno. 2014; 1(5): 313-318.
12. Kanlayavattanakul M., Lourith N. Therapeutic agents and herbs in topical applications for acne treatment. Int J cosmet Sci. 2011; 33: 289-297. 
13. Krutmann J. Pre- and probiotics for human skin. Clin Plast Surg. 2012; 39: 59– 64.
14. Scalbert A, Johnson IT, Saltmarsh M.  Polyphenols:  antioxidants  and beyond. Am J Clin Nutr. 2005; 81:215S–7S.
15. Packer L, Rimbach G, Virgili F. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med. 1999; 27(5-6):704–24, 14. 
16. Tatsuno T, Jinno M, Arima Y, Kawabata T, Hasegawa T, Yahagi N et al. Anti-inflammatory and anti-melanogenic proanthocyanidin oligomers from peanut skin. Biol Pharm Bull. 2012; 35(6):909–16.
17. Park H, Lee S, Son H, Park S, Kim M, Choi E et al. Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Arch Pharm Res. 2008; 31(10):1303–11. 15. 
18. Tzeng SH, Ko WC, Ko FN, Teng CM. Inhibition of platelet aggregation by some flavonoids. Thromb Res. 1991; 64(1):91–100.  
19. Ravindra RP,  Muslim PK. Comparison of physical characteristics of vanishing Cream base, cow ghee and shata-dhautaghrita as per pharmacopoeial standards. Int J Pharma Bio Sci. 2013; 4(4): 14 – 21.
20. Evans WC. Trease and Evans Pharmacognosy. 14th edition, WB Saunders Co. Ltd, London, 1996,545-546.
21. Wallis TE. Text book of Pharmacognosy. CBS publishers, Delhi, India, 2005, 572-575.
22. Khandelwal KR. Practical Pharmacognosy: Techniques and experiments. 4 th edition, NiraliPrakashan, India, 1998.
23. Nabavi SM, Ebrahimzadeh MA, Nabavi SF, Hamidinia A, Bekhradnia AR. Determination of antioxidant activity, phenol and flavonoid content of Parrotia Persica mey. Pharmacology online. 2008; 2:560-7.
24. Sahu Alakh N, Jha SB and Dubey SD. Formulation and Evaluation of Curcuminoid Based Herbal Face Cream. Indo-Global Journal of Pharmaceutical Sciences. 2011; 1(1): 77-84. 
25. Geneva: World Health Organization. General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine. 2000. 
26. ICH Q1C Stability testing of new dosage forms. www. Ich,org/LOB/media/MEDIA413.pdf
27. Indian Pharmacopoeia, 2007, volume I, Govt. of India, Ministry of Health and Family Welfare, Delhi: The Indian Pharmacopeia Commission, Ghaziabad, 2007.
28. Joshi PC. and Prakash O. Allelopathic effects of Litter extract of some tree species on germination and seedling growth of agricultural crops. Proceedings of the 1st National Symposium on Allopathy in Agroecosystem, (NSAA’92), Indian Society of  Alleopathy, Hisar, India. 1992, 127-128.
29. Purushotham RK, Khaliq K, Kharat SS, Sagare P, Patil SK. Preparation and evaluation o/w cream for skin psoriasis. Int J Pharma Bio Sci. 2010; 1(3):1-11.
30. Kuchekar S, Bhise K. Formulation and development of antipsoritic herbal gel cream. J  Sci Ind Res. 2012; 71:279-284.
31. Mishra S, Tiwari SK, Kakkar A, Pandey AK. Chemoprofiling of Andrographis paniculata (Kalmegh) for its andrographolide Content in Madhya Pradesh, India. Int J Pharma Bio Sci. 2010: 1(2):1-5.
32. Vandana Khattar, Ankita Wal. Utilities of Crataeva nurvala. Int J Pharm Pharm Sci. 2012; 4(4):21-26.
33. Srinivasan K, Muruganandan S, Lal J. Evaluation of anti-inflammatory activity of Pongamia pinnata leaves in rats. J Ethno pharmacol. 2001; 78:151-7.
34. Tang D, Dong Y, Ren H, Li L, He C.A review of phytochemistry, metabolite changes, and medicinal uses of the common food mung bean and its sprouts (Vigna radiata). Chem Cent J. 2014; 17; 8(1):4.
35. Neelam S, Sukhbir S, Sandeep A, Leeza B, Sonika B. International Journal of Pharmacy and Pharmaceutical Research. 2017; 9 (1): 23-36.
36. Esther O F, Liqing W, Shaobo L, Armando G, Mc Donald and Craig A Obafemi. Phytochemical analyzes from the leaves of Bryophyllum pinnatum. Europoean Journal of Medicinal Plants. 2016; 14(3):1-10.
37. Monica D. Glycyrrhiza glabra (Liquorice),A potent medicinal herb. Int J herb med. 2014; 2(2):132-136.
38. Rafie Hamidpour, Soheila Hamidpour, Mohsen Hamidpour, Mina Shahlari. Camphor (Cinnamomum camphora), a traditional remedy with the history of treating several diseases. IJCRI. Int J Case Rep Imag. 2013; 4(2):86-89.
39. Titus AMM.   The Chemistry of Food Additives and Preservatives. Wiley-Blackwell, 2012, 224–243. 
40. Panda H. Herbal Cosmetics Hand book. 3rd Revised edition, Asia Pcific Business Press Inc., New Delhi, India, 2015.  
41. Nutrition, Center for Food Safety and Applied Ingredients-Parabens in Cosmetics. www.fda.gov. 
42. Ahuja SC, Siddharth A, and Uma A. Nirgundi (Vitex negundo) Nature’s Gift to Mankind. Asian Agri Hist. 2015; 19(1):5–32.
43. Siddhartha K. Mishra, Neelam S. Sangwan and Rajender S. Sangwan. Andrographis paniculata (Kalmegh): A Review. Phcog Rev. 2007; 1(2):283-298.
44. Debjit B, Harish G, Pragati Kumar B, Duraivel S, Aravind GK, Sampath Kumar P. Medicinal uses of Punica granatum and its health benefits. J Pharmacogn Phytochem, 2013; 1(5): 28-35 
45. Ediriweera E, Premarathna N. Medicinal and cosmetic uses of Bee's Honey - A review. Ayu. 2012;33(2):178-182
46. Rajeswara Rao B.R. Biological Activities and Medicinal Uses of the Essential Oil of Lemongrass (Cymbopogon flexuosus, C. citratus, C. pendulus, C. species). Recent Progress in Medicinal Plants: Essential Oils. 1 st edition, Volume 36, Chapter 10, Studium Press LLC, Houston, USA, 2013, 213-25.
47. Kanchan Lata Singh, D. K. Singh and Vinay Kumar Singh. Multidimensional Uses of Medicinal Plant Kachnar (Bauhinia variegata Linn.) American Journal of Phytomedicine and Clinical Therapeutics. 2016; 4(2):058-072
48. Chathurvedi D, Shrivastava RRS N. Basketful benefits of citrus lemon. Int Res J Pharm, 2016; 7(6):1-4.
49. Prakash Chandra Gupta. Biological and Pharmacological properties of Terminalia chebula – An over view. Int J Pharm Pharm Sci. 2012; 4(3):62-68.
50. Kumar A, Rao K M, Han S S. Application of Xanthan gum as polysaccharide in tissue engineering: A review. Carbohyd Polym. 2018;180: 128–144. 
51. Tapanee H. Relaxing effect of Rose oil on humans. Nat Prod Commun. 2009; 4(2):291-296.
52. Kurt Kosswig. Surfactants in Ullmann's Encyclopedia of Industrial Chemistry. Weinheim,Wiley-VCH, 2005.
53. Mitusi T. New Cosmetic Science. Elsevier Science BV, 1997.
54. Baby A R, Zague V, Maciel CPM, Kaneko T M, Consiglieri V O, Velasco  MVR. Development of Cosmetics Mask Formulations. Rev Bras Cienc Farm. 2004; 40(10):159-161.
55. Quddus M A. The cropland agroforestry experiences of the village and farm forestry project in Northwest Bangladesh.. National Workshop, September 16- 17, Gazipur, Bangladesh, 2001, 229-239.
56. Singh HP, Samnhotra N, Gullaiya S, Kaur I. Anti-acne synergistic herbal face wash gel Formulation, Evaluation, and Stability study. World J Pharm Res. 2015; 4(9): 1261-1273.
57. Nayan R Bhalodia and Shukla V J. Antibacterial and antifungal activities from leaf extracts of Cassia fistula: An ethnomedicinal plant. J Adv Pharm Technol Res. 2011; 2(2): 104–109.
58. De Groot H. Reactive oxygen species in tissue injury. Hepatogastroenterology. 1994, 41:328–332. 
59. Grace PA. Ischaemia–reperfusion injury. Br J Surg. 1994, 81:637–647.
60. Letan A. The relation of structure to antioxidant activity of quercetin and some of its derivatives. J Food Sci. 1966, 31: 395–399.
61. Halliwell B. Drug antioxidant effects. A basis for drug selection. Drugs, 1991, 42: 569–605.
62. Halliwell B, Gutteridge J and Cross C. Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med. 1992, 119:598–620. 
63. Heinrich U, Moore CE, De Spirt S, Tronnier H, Stahl W. Green tea polyphenols photoprotection, increase microcirculation, and modulate skin properties of women. J Nutr. 2011; 141(6):1202-1208.   
64. Wei H, Saladi R, Lu Y, et al. Isoflavone genistein: photoprotection and clinical implications in dermatology. J Nutr. 2003; 133,11(1):3811S-3819S.   
65. Eichie FE, Matthew I A, Isesele JE, Okoh EO. Antimicrobial activity of extract and topical cream formulation of Mitracapus villosus (Rubiaceae). Journal of Pharmacy and Bioresources. 2011, 8(2).
66.   Amgad A, Awad El-Gied, Abdelkareem M, Abdelkareem, and Elnazeer I Hamedelniel. Investigation of cream and ointment on antimicrobial activity of Mangifera indica extract. J Adv Pharm Technol Res. 2015; 6(2): 53–57.

Recomonded Articles:

Author(s): Mary Charlet R. , Anuradha R.

DOI:         Access: Open Access Read More

Author(s): Vani Mamillapalli, Mounika Katamaneni, Vamsi Meghana Tiyyagura, Praneetha Kanajam, Aslesha Padmavathi Namagiri, Haripriya Thondepu, Bhavani Appikatla, Bhavana Devangam, Padmalatha Khantamneni

DOI: 10.5958/0975-4377.2020.00024.5         Access: Closed Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags