A floating extended release formulation of a broad spectrum antibiotics containing ciprofloxacin and Amoxicillin have been prepared by a unique blend of polymer (HPMC) matrix, NaHCO3 (Sodium bicarbonate) and other excipients in a optimized ratio to achieve an extended or delayed drug release profile up to 12 hours without any chemical interaction between drug and excipients. A unique blend of polymer matrix has been made by two different grades (K4M-low viscosity and K15M-high viscosity) of 'hydroxypropylmethyl cellulose' (HPMC) in a optimized ratio of 1: 35.66 (HPMC K4M: HPMC K15M) to reach the targeted drug release profile. The in vitro dissolution study shows that the floating tablets are capable of drug release over a period of 12 hours. The treated data are fitted into various kinetic models and R2 values are evaluated. The analysis shows that the drug release from the floating matrix followed Higuchi release kinetics more preferably. As the “n” (release exponent) values of Krosmeyer- Pappes model of most of the formulation batch are in the range of 0.5 – 0.89 and 0.89- 1.0.
Cite this article:
Avinash Jiddewar, N. I. Kochar. Design, Development and Optimization of Extended Release Matrix Tablet for Broad Spectrum Antibiotics. Res. J. Pharm. Dosage Form. & Tech. 2017; 9(2): 41-44. doi: 10.5958/0975-4377.2017.00008.8