Author(s): Rupali Singh, Sachi Sharma, Sonia Awatar, Dashain Purva, Arjun Singh

Email(s): arjunphar@gmail.com

DOI: 10.52711/0975-4377.2024.00019   

Address: Rupali Singh1, Sachi Sharma1, Sonia Awatar1, Dashain Purva1, Arjun Singh2*
1Department of Pharmacognosy, School of Pharmaceutical Sciences, Bhagwant University, Sikar Road, Ajmer, Rajasthan 305004, India.
2Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States.
*Corresponding Author

Published In:   Volume - 16,      Issue - 1,     Year - 2024


ABSTRACT:
Liposomal drug design has emerged as a promising approach for targeted drug delivery. This article provides an overview of the principles and strategies involved in liposomal drug design, focusing on optimizing drug stability, controlled release, and enhanced therapeutic outcomes. The composition of liposomes, including the selection of lipids, plays a crucial role in determining their properties. Size and surface modifications of liposomes enable targeted drug delivery to specific tissues or cells. Liposomes offer versatility in drug encapsulation and controlled release kinetics, improving therapeutic efficacy while minimizing side effects. Incorporating targeting ligands onto liposome surfaces enhances their affinity for diseased sites, allowing for selective drug accumulation. Stability and manufacturing considerations are vital for the successful translation of liposomal drug delivery systems. Overall, liposomal drug design holds significant potential in revolutionizing drug delivery for improved treatment outcomes.


Cite this article:
Rupali Singh, Sachi Sharma, Sonia Awatar, Dashain Purva, Arjun Singh. Advancing Therapeutics with Liposomal Drug Design: Harnessing the Potential of Liposomes for Targeted Drug Delivery. Research Journal of Pharmaceutical Dosage Forms and Technology.2024; 16(1):119-4. doi: 10.52711/0975-4377.2024.00019

Cite(Electronic):
Rupali Singh, Sachi Sharma, Sonia Awatar, Dashain Purva, Arjun Singh. Advancing Therapeutics with Liposomal Drug Design: Harnessing the Potential of Liposomes for Targeted Drug Delivery. Research Journal of Pharmaceutical Dosage Forms and Technology.2024; 16(1):119-4. doi: 10.52711/0975-4377.2024.00019   Available on: https://rjpdft.com/AbstractView.aspx?PID=2024-16-1-19


REFERENCES:
1.    Mawhoob N. Alkadasi, Abdulsalam Mohammed Alshami, H.Y. Alhabal. Study the Relation of Serum Lipids with Body Mass Index Among Students in Zabeed Education Collage, Hudaiadah University, Yemen. Asian J. Pharm. Ana. 2015; 5(1): 31-35.
2.    N. RaghavendraBabu, Y. Padmavathi, S. Priyanka, P. Ravi Kumar. Development of Sensitive Spectrophotometric Method for Analysis of Darifenacin Hydrobromide Liposomes in Rat Plasma. Asian J. Pharm. Ana. 2017; 7(1): 41-47.
3.    Audumbar Digambar Mali, Ritesh Suresh Bathe. An Updated Review on Liposome Drug Delivery System. Asian J. Pharm. Res. 2015; 5(3): 151-157.
4.    Jagdish Jadhav, Dharmendra Mundhada, Rajesh Mujoriya. Formulation Development and Evaluation of Gastro-Retentive Drug (Torsemide) Delivery System for Diuretic Drug. Asian J. Pharm. Res. 2015; 5(3): 125-130.
5.    Gawai Mamata N., Aher Smita S, Saudager Ravindra B.. A Review on Oral Osmotic ally Controlled Release Drug Delivery System. Asian J. Pharm. Res. 2016; 6(1): 49-55.
6.    Yogita R. Indalkar, Nayana V. Pimpodkar, Anita S. Godase, Puja S. Gaikwad. A Compressive Review on the Study of Nanotechnology for Herbal Drugs. Asian J. Pharm. Res. 2015; 5(4): 203-207.
7.    Gautam, Y., Dwivedi, S., Srivastava, A., Hamidullah, Singh, A., Chanda, D., Singh, J., Rai, S., Konwar, R., Negi, A.S., 2016. 2-(3′,4′-Dimethoxybenzylidene)tetralone induces anti-breast cancer activity through microtubule stabilization and activation of reactive oxygen species. RSC Adv. 6, 33369–33379.
8.    Hamid, A.A., Hasanain, M., Singh, A., Bhukya, B., Omprakash, Vasudev, P.G., Sarkar, J., Chanda, D., Khan, F., Aiyelaagbe, O.O., Negi, A.S. Synthesis of novel anticancer agents through opening of spiroacetal ring of diosgenin. Steroids. 2014; 87: 108–118.
9.    Hamid, A.A., Kaushal, T., Ashraf, R., Singh, A., Chand Gupta, A., Prakash, O., Sarkar, J., Chanda, D., Bawankule, D.U., Khan, F., Shanker, K., Aiyelaagbe, O.O., Negi, A.S. (22β,25R)-3β-Hydroxy-spirost-5-en-7-iminoxy-heptanoic acid exhibits anti-prostate cancer activity through caspase pathway. Steroids. 2014; 119: 43–52.
10.    Jain, S., Singh, A., Khare, P., Chanda, D., Mishra, D., Shanker, K., Karak, T. Toxicity assessment of Bacopa monnieri L. grown in biochar amended extremely acidic coal mine spoils. Ecological Engineering. 2017; 108: 211–219.
11.    Khwaja, S., Fatima, K., Hasanain, M., Behera, C., Kour, A., Singh, A., Luqman, S., Sarkar, J., Chanda, D., Shanker, K., Gupta, A.K., Mondhe, D.M., Negi, A.S., 2018. Antiproliferative efficacy of curcumin mimics through microtubule destabilization. European Journal of Medicinal Chemistry. 151: 51–61.
12.    Kumar, B.S., Ravi, K., Verma, A.K., Fatima, K., Hasanain, M., Singh, A., Sarkar, J., Luqman, S., Chanda, D., Negi, A.S. Synthesis of pharmacologically important naphthoquinones and anticancer activity of 2-benzyllawsone through DNA topoisomerase-II inhibition. Bioorganic and Medicinal Chemistry. 2017; 25: 1364–1373.
13.    Mishra, D., Jyotshna, Singh, A., Chanda, D., Shanker, K., Khare, P. Potential of di-aldehyde cellulose for sustained release of oxytetracycline: A pharmacokinetic study. International Journal of Biological Macromolecules. 2019; 136: 97–105.
14.    Sathish Kumar, B., Kumar, A., Singh, J., Hasanain, M., Singh, A., Fatima, K., Yadav, D.K., Shukla, V., Luqman, S., Khan, F., Chanda, D., Sarkar, J., Konwar, R., Dwivedi, A., Negi, A.S. Synthesis of 2-alkoxy and 2-benzyloxy analogues of estradiol as anti-breast cancer agents through microtubule stabilization. European Journal of Medicinal Chemistry.  2014; 86: 740–751.
15.    Sathish Kumar, B., Singh, Aastha, Kumar, A., Singh, J., Hasanain, M., Singh, Arjun, Masood, N., Yadav, D.K., Konwar, R., Mitra, K., Sarkar, J., Luqman, S., Pal, A., Khan, F., Chanda, D., Negi, A.S. Synthesis of neolignans as microtubule stabilisers. Bioorganic & Medicinal Chemistry. 2014; 22:1342–1354.
16.    Singh, A., Mohanty, I., Singh, J., Rattan, S. BDNF augments rat internal anal sphincter smooth muscle tone via RhoA/ROCK signaling and nonadrenergic noncholinergic relaxation via increased NO release. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2020; 318: G23–G33.
17.    Singh, A., Rattan, S. BDNF rescues aging-associated internal anal sphincter dysfunction. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2021; 321: G87–G97.
18.    Singh, A., Singh, J., Rattan, S. Evidence for the presence and release of BDNF in the neuronal and non‐neuronal structures of the internal anal sphincter. Neurogastroenterology & Motility.
19.    Singh, Aastha, Fatima, K., Singh, Arjun, Behl, A., Mintoo, M.J., Hasanain, M., Ashraf, R., Luqman, S., Shanker, K., Mondhe, D.M., Sarkar, J., Chanda, D., Negi, A.S.   Anticancer activity and toxicity profiles of 2-benzylidene indanone lead molecule. European Journal of Pharmaceutical Sciences. 2015; 76: 57–67.
20.    Singh, Aastha, Fatima, K., Srivastava, A., Khwaja, S., Priya, D., Singh, Arjun, Mahajan, G., Alam, S., Saxena, A.K., Mondhe, D.M., Luqman, S., Chanda, D., Khan, F., Negi, A.S. Anticancer activity of gallic acid template-based benzylidene indanone derivative as microtubule destabilizer. Chem Biol Drug Des. 2016; 88: 625–634.
21.    Manmohan, S., Arjun, S., Khan, S. P., Eram, S., &Sachan, N. K. Green chemistry potential for past, present and future perspectives. International Research Journal of Pharmacy. 2012; 3: 31-36.
22.    Singh, A., R. Sharma, K. M. Anand, S. P. Khan, and N. K. Sachan. "Food-drug interaction." International Journal of Pharmaceutical & Chemical Science. 2012; 1(1):  264-279.
23.    Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology. 2022; 12(4): 349-0. doi: 10.52711/2231-5713.2022.00055
24.    Devender Paswan, Urmila Pande, Alka Singh, Divya Sharma, Shivani Kumar, Arjun Singh. Epidemiology, Genomic Organization, and Life Cycle of SARS CoV-2. Asian Journal of Nursing Education and Research. 2023; 13(2):141-4.
25.    Arjun Singh, Rupendra Kumar, Sachin Sharma. Natural products and Hypertension: Scope and role in Antihypertensive Therapy. Asian Journal of Nursing Education and Research. 2023; 13(2): 162-6.
26.    Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology; 12(4): 349-0.
27.    Arjun Singh, Rupendra Kumar. An Overview on Ethnopharmacological, Phytochemical, and Clinical Significance of Selected Dietary Polyphenols. Asian Journal of Research in Chemistry. 2023; 16(1): 8-2.
28.    Arjun Singh. Plant-based Isoquinoline Alkaloids: A Chemical and Pharmacological Profile of Some Important Leads. Asian Journal of Research in Chemistry. 2023; 16(1): 43-8.
29.    Singh, A., Chanda, D., and Negi, A. S. Antihypertensive activity of Diethyl-4, 4'-dihydroxy-8, 3'-neolign-7, 7'-dien-9, 9'-dionate through increase in intracellular cGMP level and blockade of calcium channels (VDCC) and opening of potassium channel and in vivo models (SHRs and L-NAME induced hypertension). In Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology) (pp. PO1-2). Japanese Pharmacological Society.
30.    Pumila Singh, Divya Sharma, Varsha Singh, Sheila Kumari, Arjun Singh, Hema Jain. Management of Non-hospitalized patients with Acute SARS-CoV-2 (COVID-19) viral infection in among human adult population. Asian Journal of Management. 2023; 14(4):227-2. doi: 10.52711/2321-5763.2023.00038
31.    Arjun Singh. Withaniasomnifera (L.) Ashwagandha: A Review on Ethnopharmacology, Phytochemistry, Biomedicinal and Traditional uses. Asian Journal of Pharmacy and Technology. 2023; 13(3): 213-7. doi: 10.52711/2231-5713.2023.00038
32.    Arjun Singh. An Overview on Phytoestrogen based antihypertensive agent for their potential Pharmacological Mechanism. Research Journal of Pharmaceutical Dosage Forms and Technology. .2023; 15(3): 211-4. doi: 10.52711/0975-4377.2023.00034
33.    Arjun Singh, Rupendra Kumar, Sachin Sharma. Natural products and Hypertension: Scope and role in Antihypertensive Therapy. Asian Journal of Nursing Education and Research. 2023; 13(2): 162-6. doi: 10.52711/2349-2996.2023.00035
34.    Kaman Kumar, Pooja Singh, Divya Sharma, Akanksha Singh, Himanshu Gupta, Arjun Singh. Prospective Current Novel Drug Target for the Identification of Natural Therapeutic Targets for Alzheimer's Disease. Asian Journal of Pharmacy and Technology. 2023; 13(3): 171-4. doi: 10.52711/2231-5713.2023.00030
35.    Singh, A. Brain-derived neurotrophic factor – a key player in the gastrointestinal system. Gastroenterology Review/ Przegląd Gastroenterologiczny. 2023; 18(4): 380-392. https://doi.org/10.5114/pg.2023.132957
36.    Devender Paswan, Urmila Pande, Alka Singh, Divya Sharma, Shivani Kumar, Arjun Singh. Epidemiology, Genomic Organization, and Life Cycle of SARS CoV-2. Asian Journal of Nursing Education and Research. 2023; 13(2): 141-4. doi: 10.52711/2349-2996.2023.00031
37.    Arjun Singh. Plant-based Isoquinoline Alkaloids: A Chemical and Pharmacological Profile of Some Important Leads. Asian Journal of Research in Chemistry. 2023; 16(1):43-8. doi: 10.52711/0974-4150.2023.00008

Recomonded Articles:

Author(s): Domendra Sahu, Shekhar Verma , Ravindra D. Dubey

DOI:         Access: Open Access Read More

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Suyash Ingle, Varsha Tegeli, Akshay Javalgikar, Vinod Matole, Lagmanna koli, Avinash Birajdar, Saurabh Nangare, Sagar Adlinge, Swaminath Ramanshetti, Akhil Patil, Yash Kothari, Pandurang Choure, Aaqueeb Mangalgiri, Sneha Ubale, Vaishnavi Dulange, Bhavana habib, Jyoti Mittha

DOI: 10.5958/0975-4377.2021.00013.6         Access: Open Access Read More

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0         Access: Open Access Read More

Author(s): Vijay Chudiwal, Sadhana Shahi

DOI: 10.5958/0975-4377.2016.00003.3         Access: Open Access Read More

Author(s): Varsha R. Sandhan, S.B. Gondkar, R. B. Saudagar

DOI:         Access: Open Access Read More

Author(s): Doppalapudi Sandeep, A. P. Pratyusha, G. Sudheshna, K. Lakshmi prasanna, P. Sreekanth

DOI:         Access: Open Access Read More

Author(s): Sushant R. Jagtap, D.G Phadtare, R.B. Saudagar

DOI: 10.5958/0975-4377.2016.00021.5         Access: Open Access Read More

Author(s): Swati S Talokar, Rohan R Vakhariya

DOI: 10.5958/0975-4377.2017.00001.5         Access: Open Access Read More

Author(s): Patil Amol M, Todkar Rohit R, Gumte Dipak S, S.K. Mohite, C.S. Magdum

DOI: 10.5958/0975-4377.2016.00030.6         Access: Open Access Read More

Author(s): Saikumar Y., Saikishore V., Pavani K., Sairam D.T., Sindhura A.

DOI:         Access: Open Access Read More

Author(s): N.L Prasanthi, S.S. Manikiran, C. Sowmya Krishna, N. Rama Rao

DOI:         Access: Open Access Read More

Author(s): V. Kalyani, K. Basanthi , T.E.G.K. Murthy

DOI:         Access: Open Access Read More

Author(s): Patel Chirag J., Asija Sangeeta, Patel Pinkesh, Mangukia Dhruv, Satyanand Tyagi

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags