Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)


Submit Article

Method Development and Validation of Canagliflozin by using RP-HPLC in Pure and Tablet Dosage Form

Author(s): Swapna Singh, Prem Kumar Bichala, Abhishek Agrawal

Email(s): swapnasingh112@gmail.com

DOI: 10.52711/0975-4377.2021.00037   

Address: Swapna Singh*, Prem Kumar Bichala, Abhishek Agrawal
School of Pharmaceutical Sciences, Pratap University, Sunderpura – 303104, Jaipur, Rajasthan, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 3,     Year - 2021

 View HTML        View PDF

ABSTRACT:
A new method was established for simultaneous estimation of Canagliflozin by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Canagliflozin by using INERTSIL column, C18 (150x4.6)5µm column, flow rate was 1ml/min, mobile phase ratio was Water: Acetonitrile (70:30), detection wavelength was 264nm. The instrument used was Hitachi HPLC Auto Sampler, Separation module 1575. The analytical method was validated according to ICH guidelines (ICH, Q2 (R1)). The linearity study for Canagliflozin was found in concentration range of 1µg-5µg and 100µg-500µg and correlation coefficient (r2) was found to be 0.999 and 0.999, %mean recovery was found to be 100% and 100.5%, %RSD for repeatability was 0.2 and 0.4, %RSD for intermediate precision was 0.5 and 0.1 respectively.


Keywords:

Cite this article:
Swapna Singh, Prem Kumar Bichala, Abhishek Agrawal. Method Development and Validation of Canagliflozin by using RP-HPLC in Pure and Tablet Dosage Form. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(3):209-2. doi: 10.52711/0975-4377.2021.00037

Cite(Electronic):
Swapna Singh, Prem Kumar Bichala, Abhishek Agrawal. Method Development and Validation of Canagliflozin by using RP-HPLC in Pure and Tablet Dosage Form. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(3):209-2. doi: 10.52711/0975-4377.2021.00037   Available on: https://rjpdft.com/AbstractView.aspx?PID=2021-13-3-8


REFERENCE:
1.    International Conference on Harmonization, "Q2A: Text on Validation of Analytical Procedures," Federal Register. 1995, 60, 11260–11262.
2.    Ghulam, A. S. PLC Method Development and Validation for Pharmaceutical Analysis. Pharmaceutical Technology Europe. 2004, 7, 55 -63.
3.    Radhika, R.; Alfred, D. G. Guidance for Industry- Analytical Procedures and Methods Validation. Federal Register, 2000, 2396, 1-32.
4.    https://www.drugbank.ca/drugs/DB08907
5.    Sandouk P, Bouvierd'Yvoire M, Chretien P, Tillement JP, Scherrmann JM (January 1994). "Single-dose Apixaban in healthy volunteers". Biopharmaceutics and Drug Disposition 15 (1): 87–92.doi:10.1002/bdd.2510150108. PMID 8161719.

Recomonded Articles:

Formulation Development and Evaluation of Capsule Containing Fluclaxacillin Sodium and Amoxicillin Trihydrate with Enteric Coated Granules of Lactic Acid Bacillus

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI:         Access: Open Access Read More

Cleaning Validation of Paracetamol Tablets as a Dosage Formulation

Author(s): Hapse S.A., Bhagat B.V., Wagh V.S. , Kadaskar P.T.

DOI:         Access: Open Access Read More

Transdermal Drug Delivery System of Antidiabetic Drugs: A Review

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Isolation and evaluation of Basella alba linn. Leaf mucilage as release retardant in tablet formulation

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Enhancement of Solubility of Poorly Water Soluble Drug (Allopurinol) Through Solid Dispersion

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Formulation and In vitro Evaluation of Immediate Release Bilayer Tablets of Telmisartan and Amlodipine Besylate

Author(s): Soham Shukla, Vikram Pandya, Praful Bhardia, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Deependra Jain

DOI:         Access: Open Access Read More

Formulation Development of a Nutraceutical product comprising Manilkara zapota Fruit Pulp

Author(s): Rebello Norma, Bhalerao Suhasini

DOI: 10.5958/0975-4377.2016.00035.5         Access: Open Access Read More

Self Microemulsifying Drug Delivery System (SMEDDS): A Novel Approach to Improve the Therapeutic Efficacy of Orally Administered Drug

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0         Access: Open Access Read More

Design, Development and Evaluation of Solifenacin Succinate Tablets

Author(s): R. K.V. Naga Sudha, V. Sai Kishore, CH. Venu Babu, E. Jitendranath

DOI: 10.5958/0975-4377.2015.00016.6         Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Buccal Patch of Saxagliptin Hydrochloride

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Patent Perspective of Advanced Gastroretentive Drug Delivery Systems

Author(s): Vijay Chudiwal, Sadhana Shahi

DOI: 10.5958/0975-4377.2016.00003.3         Access: Open Access Read More

Influence of Different Beverages on Disintegration Behavior of Pain Reliever Immediate Release Formulations

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Formulation and Evaluation of Transdermal Patch of Aceclofenac

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI:         Access: Open Access Read More

A Brief Review on Intra-Uterine Drug Delivery Systems

Author(s): Suyash Ingle, Varsha Tegeli, Akshay Javalgikar, Vinod Matole, Lagmanna koli, Avinash Birajdar, Saurabh Nangare, Sagar Adlinge, Swaminath Ramanshetti, Akhil Patil, Yash Kothari, Pandurang Choure, Aaqueeb Mangalgiri, Sneha Ubale, Vaishnavi Dulange, Bhavana habib, Jyoti Mittha

DOI: 10.5958/0975-4377.2021.00013.6         Access: Open Access Read More

Stability Indicating RP-HPLC Method for the Estimation of Memantine Hydrochloride in Pure and Pharmaceutical Dosage Form

Author(s): B. Thangabalan, Ch. Sandhya, N. Sunitha, S. Manohar Babu

DOI:         Access: Open Access Read More

Formulation Development and Evaluation of Sodium Valproate and Valproic acid Extended Release Tablets

Author(s): K. Vanitha, Prasanna Kumar Desu

DOI: 10.5958/0975-4377.2019.00012.0         Access: Open Access Read More

Formulation and Development of Ethyl cellulose coated Pectin based Capecitabine Loaded Microspheres for Colorectal Cancer

Author(s): Dilip M. Kumbhar, Kailas K. Mali, Remeth J. Dias, Vijay D. Havaldar, Vishwajeet S. Ghorpade, Nitin H. Salunkhe.

DOI: 10.5958/0975-4377.2016.00036.7         Access: Open Access Read More

Enzyme Immobilization: A Bridge of Understanding between Biotechnology and Pharmacy

Author(s): Nisha Nair, Amrita Thakur, Mukta Agrawal, Juhi Thakur,Shubhangi Gupta, Bharti Sahu, Devendra kumar, Indu Rai, Jaya Sonkar, Kalyani Sahu, Kuldeep, Kailash Kumar, Muktanand, Nidhi Kaushik, Omkar Sahu, Somsunder Sahu, Umesh Kumar, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0975-4377.2018.00017.4         Access: Open Access Read More

Development and Validation of a Simultaneous HPLC Method for Assay and Dissolution of Bisoprolol fumarate and Amlodipine besylate in Pharmaceutical Dosage.

Author(s): Shalini Pant, Krishan Pal

DOI:         Access: Open Access Read More

Formulation and Evaluation of mucoadhesive buccal patches of Terbutaline Sulphate

Author(s): Suresh A. Marnoor

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 

Quick Links


Latest Issues

Popular Articles


Recent Articles



Preparation and Optimization of Fexofenadine HCl Solid lipid Nanoparticles
An Overview on Phytoestrogen based antihypertensive agent for their potential Pharmacological Mechanism
Design and Formulation for Enhancement of Solubility and Dissolution Rate of Atorvastatin using Solid Dispersion
In-vitro Assessment of Antiurolithiatic activity of Tridax procumbens Flower Extracts
Preparation and Evaluation of Aceclofenac microsphere containing Natural gum
Formulation and Development of Solid Dispersion System for Enhancement of Solubility and Dissolution Rate of Lovastatin
Development of Liposomal Encapsulated Silver Sulfadiazine Gel for Burn Therapy
RP-HPLC Method Development and Validation for the Estimation of Lafutidine using Bulk and Pharmaceutical Dosage Forms
pH Sensitive Hydrogel: A Review
A Review on Nutraceuticals and its Classification
A Cutting-Edge Method for Regulated Drug Delivery - Microencapsulation
Formulation and Evaluation of Conditioning Herbal Shampoo
Formulation and Evaluation of Mucoadhesive In-situ Nasal Gel of Tramadol Hydrochloride
A Review on the many different types of Polymers that are Utilized in the Production of in Situ Gels
Formulation for Enhancement of Solubility and Dissolution Rate of Simvastatin using Solid Dispersion
Ethnobotanical Study of Antifungal Medicinal plant in the region of El Bayadh (Algeria)
Formulation and Evaluation as Sustain Released Nanoparticles for Zolmitriptan Hydrochloride for the enhanced Bioavailability and Better Therapeutic Action by using Chitosan as a Permeation Enhancer
Liposomes containing azithromycin and green tea as an anti-acne treatment: Formulation and Characterization
Design, Fabrication, and Analysis of Resveratrol and Piperine-Loaded Chitosan Nanoparticles with the Purpose of Providing an Enhanced Parkinson
Design, Development and Formulation of Mucoadhesive In-situ Nasal Gel of Meperidine Hydrochloride

Tags


About Journal

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 485
Yesterday: 652
Total: 648872