Author(s): Swapna Singh, Prem Kumar Bichala, Abhishek Agrawal

Email(s): swapnasingh112@gmail.com

DOI: 10.52711/0975-4377.2021.00037   

Address: Swapna Singh*, Prem Kumar Bichala, Abhishek Agrawal
School of Pharmaceutical Sciences, Pratap University, Sunderpura – 303104, Jaipur, Rajasthan, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 3,     Year - 2021


ABSTRACT:
A new method was established for simultaneous estimation of Canagliflozin by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Canagliflozin by using INERTSIL column, C18 (150x4.6)5µm column, flow rate was 1ml/min, mobile phase ratio was Water: Acetonitrile (70:30), detection wavelength was 264nm. The instrument used was Hitachi HPLC Auto Sampler, Separation module 1575. The analytical method was validated according to ICH guidelines (ICH, Q2 (R1)). The linearity study for Canagliflozin was found in concentration range of 1µg-5µg and 100µg-500µg and correlation coefficient (r2) was found to be 0.999 and 0.999, %mean recovery was found to be 100% and 100.5%, %RSD for repeatability was 0.2 and 0.4, %RSD for intermediate precision was 0.5 and 0.1 respectively.


Cite this article:
Swapna Singh, Prem Kumar Bichala, Abhishek Agrawal. Method Development and Validation of Canagliflozin by using RP-HPLC in Pure and Tablet Dosage Form. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(3):209-2. doi: 10.52711/0975-4377.2021.00037

Cite(Electronic):
Swapna Singh, Prem Kumar Bichala, Abhishek Agrawal. Method Development and Validation of Canagliflozin by using RP-HPLC in Pure and Tablet Dosage Form. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(3):209-2. doi: 10.52711/0975-4377.2021.00037   Available on: https://rjpdft.com/AbstractView.aspx?PID=2021-13-3-8


REFERENCE:
1.    International Conference on Harmonization, "Q2A: Text on Validation of Analytical Procedures," Federal Register. 1995, 60, 11260–11262.
2.    Ghulam, A. S. PLC Method Development and Validation for Pharmaceutical Analysis. Pharmaceutical Technology Europe. 2004, 7, 55 -63.
3.    Radhika, R.; Alfred, D. G. Guidance for Industry- Analytical Procedures and Methods Validation. Federal Register, 2000, 2396, 1-32.
4.    https://www.drugbank.ca/drugs/DB08907
5.    Sandouk P, Bouvierd'Yvoire M, Chretien P, Tillement JP, Scherrmann JM (January 1994). "Single-dose Apixaban in healthy volunteers". Biopharmaceutics and Drug Disposition 15 (1): 87–92.doi:10.1002/bdd.2510150108. PMID 8161719.

Recomonded Articles:

Author(s): Suyash Ingle, Varsha Tegeli, Akshay Javalgikar, Vinod Matole, Lagmanna koli, Avinash Birajdar, Saurabh Nangare, Sagar Adlinge, Swaminath Ramanshetti, Akhil Patil, Yash Kothari, Pandurang Choure, Aaqueeb Mangalgiri, Sneha Ubale, Vaishnavi Dulange, Bhavana habib, Jyoti Mittha

DOI: 10.5958/0975-4377.2021.00013.6         Access: Open Access Read More

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI:         Access: Open Access Read More

Author(s): Deore Nisha N., R. K. Surawase

DOI: 10.52711/0975-4377.2022.00055         Access: Open Access Read More

Author(s): Hapse S.A., Bhagat B.V., Wagh V.S. , Kadaskar P.T.

DOI:         Access: Open Access Read More

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0         Access: Open Access Read More

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI:         Access: Open Access Read More

Author(s): Soham Shukla, Vikram Pandya, Praful Bhardia, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Deependra Jain

DOI:         Access: Open Access Read More

Author(s): Amallia Rachmasari, Rafidha Aisyah Kartini, Gita Alviani, Indah Solihah

DOI: 10.5958/0975-4377.2019.00046.6         Access: Open Access Read More

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Author(s): Sayad Basha.K, Sheema Nafees. S, Nethravani. G, Thirumalesh Naik S.B

DOI: 10.5958/0975-4377.2016.00015.X         Access: Open Access Read More

Author(s): R. K.V. Naga Sudha, V. Sai Kishore, CH. Venu Babu, E. Jitendranath

DOI: 10.5958/0975-4377.2015.00016.6         Access: Open Access Read More

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Author(s): Vijay Chudiwal, Sadhana Shahi

DOI: 10.5958/0975-4377.2016.00003.3         Access: Open Access Read More

Author(s): B. Thangabalan, Ch. Sandhya, N. Sunitha, S. Manohar Babu

DOI:         Access: Open Access Read More

Author(s): Varsha R. Sandhan, S.B. Gondkar, R. B. Saudagar

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags