Author(s): Naimish Patoliya, Bhavna Joshi, Umesh Upadhyay

Email(s): davidpatoliya@gmail.com

DOI: 10.5958/0975-4377.2021.00012.4   

Address: Naimish Patoliya¹, Prof. Bhavna Joshi2, Dr. Umesh Upadhyay3
1Student, Department of Pharmacy, Sigma Institute of Pharmacy, Bakrol, Ajwa, Vadodara.
2Associate Professor, Department of Pharmacy, Sigma Institute of Pharmacy, Bakrol, Ajwa, Vadodara.
3Principal, Department of Pharmacy, Sigma Institute of Pharmacy, Bakrol, Ajwa, Vadodara.
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2021


ABSTRACT:
Many conventional dosage forms come in the market to achieve their therapeutic value as they administered via various routes. The dosage form is a imply used for the transport of drugs to a living body. To get the desired effect, the drug should be delivered to its site of action at such rate and concentration to acquire the maximum therapeutic effect and minimal adverse effect. The oral administration route is considered to be the most widely preferred route by patients, because of its convenience of administration and easy of manufacturing. Oral Dosage Forms, like orally disintegrating tablets (ODTs), Conventional tablets, Sublingual tablets, and Delay-release tablets. Orally disintegrating tablets differ from the traditional marketed tablets, in that they are designed to be dissolved on the tongue rather than swallowed whole. Oral disintegrating tablets (ODTs) are a novel dosage form that can be put on the tongue they disintegrate instantly, releasing the drug which dissolves or disperse in the saliva fluid, dissolved on the tongue inside 3-4 min or less, especially for geriatric and pediatric patients. By introducing into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water is a major throwback of conventional tablets. Nowadays, ODTs have received ever-increasing demand and this particular field has become a rapidly growing area in the pharmaceutical industry developments. ODTs are Quick absorption, rapid onset of action, and reduction in drug loss properties are the basic advantages of this dosage form. After the development of final formulations, evaluation of these tablets was done by like weight variation, hardness testing, friability tester, disintegration, the drug to polymer interaction, drug content, water absorption ratio, wetting time, and in-vitro drug release and stability studies.


Cite this article:
Naimish Patoliya, Bhavna Joshi, Umesh Upadhyay. Future Prospect of Oral Disintegration drug Delivery system: A Review. Res. J. Pharma. Dosage Forms and Tech.2021; 13(1):66-71. doi: 10.5958/0975-4377.2021.00012.4

Cite(Electronic):
Naimish Patoliya, Bhavna Joshi, Umesh Upadhyay. Future Prospect of Oral Disintegration drug Delivery system: A Review. Res. J. Pharma. Dosage Forms and Tech.2021; 13(1):66-71. doi: 10.5958/0975-4377.2021.00012.4   Available on: https://rjpdft.com/AbstractView.aspx?PID=2021-13-1-12


REFERENCE:
1.    Hirani J, Rathod D, Vadalia K. Orally disintegrating tablets. Tropical Journal of Pharmaceutical Research 2009;8(2): 161-172.
2.    Konapure SA, Chaudhari PS, Oswal RJ, Kshirsagar SS, Antre RV, Chorage TV. Mouth dissolving tablets an innovative technology. International Journal of Applied Biology and Pharmaceutical Technology 2011;2(1): 496- 503.
3.    Bangale SG, Shinde GV, Rathinaraj BS. New generation of orodispersible tablets: recent advances and future prospects. International Journal of Advances in Pharmaceutical Sciences 2011;2(3): 17-28.
4.    Jesmeen T, Uddin R. Orodispersible tablets: A short review. Stamford Journal of Pharmaceutical Sciences 2011;4(1): 96-99
5.    Clarke A, Brewer F, Johnson ES, Mallard N, Hartig F, Taylor S, et al. A new formulation of selegiline: improved bioavailability and selectivity for MAO-B inhibition. Journal of Neural Transmission 2003;110(11): 1241- 1255.
6.    Bhowmik D, Chiranjib P, Krishnakanth, Chandira RM. Fast dissolving tablet: An overview. Journal of Chemical and Pharmaceutical Research 2009;1(1): 163- 177.
7.    Agarval VA, Rajkumar RM, Ingale RG. Fast disintegrating tablet as new drug delivery system: A review. Pharmacophore 2011;2(1): 81-88.
8.    Deshmukh VN. Mouth dissolving drug delivery system: A review. International Journal of PharmTech Research 2012;4(1): 412-421.
9.    Brown D. Orally disintegrating tablets-taste over speed. Drug Delivery Technology 2003;3(6): 58-61.
10.    Pilgaonkar P, Rustomjee M, Gandhi A, Badge PM. Orally disintegrating tablets. United States Patent. 2009.
11.    Shukla D, Chakarborty S. Mouth dissolving tablets: An overview of formulation technology. Scientia Pharmaceutica 2009;77 (2): 309-326.
12.    Kumare MM, Marathe RP, Kawade RM, Ghante MH, Shendarkar GR. Design of fast dissolving tablet of atenolol using novel coprocessed superdisintegrant. Asian Journal of Pharmaceutical and Clinical Research 2013;6 (3): 81-85.
13.    Chacko AJ, Jose S, Babu N, Lucille, Michelle M. Design and development of orodispersible tablets of promethazine theoclate using coprocessed superdisintegrants and subliming materials. International Journal of Innovative Pharmaceutical Research 2010;1(2): 53-56.
14.    Saxena V, Khinchi MP, Gupta MK, Agarwal D, Sharma N. Orally Disintegrating Tablets: Friendly Dosage Form. International Journal of Research in Ayurveda and Pharmacy. 2010; 1: 399-407.
15.    Virely P, Yarwood R. Zydis – a novel, Fast Dissolving Dosage Form. Manuf Chem. 1990; 61: 36-37
16.    Seager H. Drug delivery products and the zydis fast dissolving dosage form. Journal of Pharmacy and Pharmacology 1998;50(4): 375-382.
17.    Habib W, Khankari R, Hontz J. Fast dissolving drug delivery system. Critical Reviews in Therapeutic Drug Carrier Systems 2000; 17(1):61-72.
18.    Behnke K, Sogaard J, Martin S, Bauml J, Ravindran AV, Agren H, et al. Mirtazapine orally disintegrating tablet versus sertraline: a prospective onset of action study. Journal of Clinical Psychopharmacology 2003;23(4): 358-364.
19.    Gafiţanu E, Dumistracel I, Antochi S. Formulations and bioavailability of propyphenazone in lyophilized tablets. Revista Medico-chirurgicala a Societatii De Medici Si Naturalisti Din Iasi 1991;95(1- 2): 127-128.
20.    Kumari S, Visht S, Sharma PK, Yadav RK. Fast Dissolving Drug Delivery System: Review Article. Journal of Pharmacy Research. 2010; 3(6): 1444- 1449. 18. Bhowmik D, Chranjib B, Pankaj K, Chandira RM. Fast Dissolving Tablet: An Overview. Journal of Chemical and Pharmaceutical Research. 2009; 1(1): 163-177.
21.    Ashish P, Harsoliya MS, Pathan JK, Shruti S. A review-formulation of mouth dissolving tablet. Int J Pharm Clin Sci 2011; 1:1-8.
22.    Allen LV Jr. Dosage form design and development. Clin Ther 2008; 30: 2102-11
23.    Kumari S, Visht S, Sharma PK, Yadav RK. Fast dissolving Drug delivery system: Review Article; Journal of Pharmacy Research 2010; 3(6): 1444-1449.
24.    Mahato RI, Narang AS. Drug delivery systems. In: Pharmaceutical Dosage Forms and Drug Delivery. 2nd ed. New York: CRC Press; 2011. p. 217-34.
25.    Nagar P, Singh K, Chauhan I, Verma M, Yasir M, Khan A, et al. Orally disintegrating tablets: Formulation, preparation techniques and evaluation. J App Pharm Sci 2011; 4: 35-45.
26.    Pahwa R, Piplani M, Sharma PC, Kaushik D, Nanda S. Orally disintegrating tablets-Friendly to pediatrics and geriatrics. Arch Appl Sci Res 2010; 2:35-48
27.    Bhowmik D, Chiranjib B, Pankaj. Fast dissolving tablet: An overview. J Chem Pharm Res 2009;1: 163-77.
28.    Nagar P, Singh K, Chauhan I, Verma M, Yasir M, Khan A, et al. Orally disintegrating tablets: Formulation, preparation techniques and evaluation. J App Pharm Sci 2011;4: 35-45.
29.    Sehgal P et al. Fast dissolving tablets: a new venture in drug delivery. American Journal of PharmTech Research 2012; 2(4):252-279.
30.    Parkash V, Maan S, Deepika, Yadav SK, Hemlata, Jogpal V. Fast disintegrating tablets: Opportunity in drug delivery system. J Adv Pharm Technol Res 2011;2: 223-35.
31.    Kuchekar BS, Badhan AC, Mahajan HS. Mouth dissolving tablets: A novel drug delivery system. Pharm Times 2003;35: 7-14.
32.    Sri KV, Raj GB, Ravishanker D, Kumar CA. Preparation and evaluation of montelukast oral dispersible tablets by direct compression method. Int Res J Pharm 2012;7: 315-18.
33.    Shukla D, Chakraborty S, Singh S, Mishra B. Mouth dissolving tablets I: An overview of formulation technology. Sci Pharm 2009; 77:309-26.
34.    Yang D, Kulkarni R, Behme RJ, Kotiyan PN. Effect of the melt granulation technique on the dissolution characteristics of griseofulvin. Int J Pharm 2007; 329:72-80.
35.    Bess WS, Kulkarni N, Ambike SH, Ramsay MP. Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1. United States Patent; US 7067116; 2006.
36.    Fatma R, Nandi PK, Gupta AK. Novel approach for patient’s compliance: fast dissolving tablets. World Journal of Pharmacy and Pharmaceutical Sciences 2014;3(7):1758-1768.
37.    Tablet rapidly disintegrating in the oral cavity, Chem Pharm Bull, 1996; 44: 2121-2127.
38.    Subramanian S, Sankar V, Manakadan AA, Ismailand S, Andhuvan G. Formulation and Evaluation of Cetirizine dihydrochloride Orodispersible Tablet. Pak.J.Pharm. Sci. 2010; 239 (2): 232-235.
39.    Kuno Y, Kojima M, Ando S, Nakagami H. Evaluation of Rapidly Disintegrating Tablets Manufactured by Phase Trasition of Sugar Alcohol. Journal of Controlled Release. 2005; 105: 16-22.
40.    Bhowmik D, Chiranjib B, Pankaj. Fast dissolving tablet: An overview. J Chem Pharm Res 2009;1: 163-77.
41.    Chaudhari PD, Chaudhari SP, Kolhe SR, Dave KV, More DM. Formulation and evaluation of fast dissolving tablets of famotidine. Indian Drugs 2005; 42: 641- 649.
42.    Wilson CG, Washington N, Norman S, Greaves JL, Peach JM, Pugh K. A gamma scintigraphic study to compare oesophageal clearance of “Expidet” formulation, tablets and capsules in supine volunteers. Int. J.Pharm. 1988; 46 (3): 241-246.
43.    Washington N, Wilson CG, Greaves JL, Norman S, Peach JM, Pugh K. A gamma scintigraphic study of gastric coating by Expidet, tablets and liquid formulation. Int. J. Pharm. 1989; 57(1): 17-22.
44.    Divate S, Kunchu K, Sockan GN. Fast Disintegrating tablet an Emerging Trend. International Journal of Pharmaceutical Science Review and Research. 2011; 6 (2): 18-22.

Recomonded Articles:

Author(s): Vinod K.R., Sandhya S

DOI:         Access: Open Access Read More

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI:         Access: Open Access Read More

Author(s): V. S. Parmar, S.C. Shivhare

DOI:         Access: Open Access Read More

Author(s): Hapse S.A., Bhagat B.V., Wagh V.S. , Kadaskar P.T.

DOI:         Access: Open Access Read More

Author(s): Pratik Swarup Das, Puja Saha1, Krishan, Rumpa Das

DOI: :10.5958/0975-4377.2018.00005.8         Access: Open Access Read More

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Dipti G. Phadtare, Amol R. Pawar, R.B. Saudagar, Govind K.Patil

DOI: 10.5958/0975-4377.2017.00002.7         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6         Access: Open Access Read More

Author(s): Dharmendra Kumar Kushwah, Prakash Yashwant Kohle, Bimal Kumar Srivastava, Manoj Parmar ,Dhaval Mehta

DOI:         Access: Open Access Read More

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0         Access: Open Access Read More

Author(s): Debarupa Dutta, Prithviraj Chakraborty

DOI:         Access: Open Access Read More

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Author(s): Vijay Chudiwal, Sadhana Shahi

DOI: 10.5958/0975-4377.2016.00003.3         Access: Open Access Read More

Author(s): B. Thangabalan, Ch. Sandhya, N. Sunitha, S. Manohar Babu

DOI:         Access: Open Access Read More

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Author(s): Varsha R. Sandhan, S.B. Gondkar, R. B. Saudagar

DOI:         Access: Open Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, Darsh Gautam, Parshuram Rai, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2017.00022.2         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags