Detailed Review of Shatdhaut Ghrita as a Base in Moisturizing Cream

 

 Mayur Chavan1, Rushikesh Bachhav2, Mayur Bhamare2, Yogesh Sharma2,

Khemchand Surana2, Shivraj Jadhav2, Sunil Mahajan2

1Department of Pharmaceutics, Divine College of Pharmacy, Satana, Nashik,

Affiliated by Savitribai Phule Pune University, Maharashtra 423301.

2Department of Pharmaceutical Quality Assurance, Divine College of Pharmacy, Satana, Nashik,

Affiliated by Savitribai Phule Pune University, Maharashtra 423301.

*Corresponding Author E-mail: mayurchavan62204@gmail.com

 

ABSTRACT:

Shatdhaut Ghrita (SDG), an Ayurvedic preparation of clarified butter (ghee) washed 100 times with water, has been traditionally used for its therapeutic properties in skin care. This review evaluates its efficacy and potential as a base in moisturizing cream formulations. The literature highlights SDG's unique physicochemical properties, including enhanced bioavailability, stability, and penetration potential due to nanoscale particle size and emulsion formation. SDG's composition—rich in short- and medium-chain fatty acids, antioxidants, and anti-inflammatory compounds—provides significant hydration, skin barrier repair, and wound healing benefits. The review also explores SDG’s compatibility with other excipients, showing its capacity to form stable emulsions and enhance the delivery of active pharmaceutical ingredients. Studies confirm its role in reducing transepidermal water loss (TEWL), alleviating conditions like eczema, psoriasis, and dry skin. Challenges in formulating with SDG, such as odor masking and standardization, are addressed with modern techniques.In conclusion, Shatdhaut Ghrita demonstrates excellent potential as a natural and effective base for moisturizing creams, warranting further clinical and formulation studies to standardize its use in modern cosmeceuticals.

 

KEYWORDS: Shatdhaut Ghrita, Moisturizing Cream, Ayurvedic Formulation, Skin Hydration, Natural Base, Cosmeceuticals.

 

 


INTRODUCTION TO SHATDHAUT GHRITA1,2

Shatdhaut Ghrita is a time-honored Ayurvedic preparation renowned for its exceptional properties in skin nourishment, hydration, and rejuvenation. Derived from the Sanskrit words “Shat” (meaning 100) and “Dhaut” (meaning washed), Shatdhaut Ghrita is clarified butter (ghee) that has undergone a meticulous process of being washed with water 100 times. This practice is believed to purify the ghee and render it more beneficial for topical use, making it a highly regarded base for Ayurvedic skin creams, especially for moisturizing and healing.

While ghee itself has long been praised for its ability to moisturize and heal, the special preparation of Shatdhaut Ghrita enhances its therapeutic potential for skincare by eliminating excess greasiness while retaining its potent nourishment properties. When used as a base in moisturizing creams, Shatdhaut Ghrita provides unique benefits for both dry and sensitive skin, making it a promising ingredient in modern cosmetic formulations.

 

This review explores the efficacy, properties, and potential benefits of using Shatdhaut Ghrita as a base in moisturizing creams, drawing from both traditional Ayurvedic wisdom and contemporary scientific understanding.

 

1. Composition and Preparation of Shatdhaut Ghrita3

How Shatdhaut Ghrita Is Made:

Shatdhaut Ghrita begins with the preparation of traditional clarified butter, or ghee, which is made by simmering unsalted butter to separate the milk solids from the fat. The process of making Shatdhaut Ghrita involves repeatedly washing this ghee in water, typically 100 times. Each wash purifies the ghee by removing impurities, such as excess oils and particulates, and enhances its ability to be absorbed by the skin.

 

After the washing process, the ghee retains its rich composition of lipids and fatty acids but becomes lighter and more emollient, improving its skin compatibility. The result is a creamy, smooth, and nourishing base that is well-suited for cosmetic formulations.

 

Primary Components of Shatdhaut Ghrita4

·       Ghee (Clarified Butter): Ghee is made from butter through a process of heating and separating the milk solids. It is rich in essential fatty acids, including butyrate and medium-chain fatty acids, which contribute to its anti-inflammatory, moisturizing, and healing properties. Additionally, ghee contains fat-soluble vitamins like A, D, E, and K.

·       Water: Water is used to wash the ghee, which helps purify the ghee and enhances its ability to penetrate the skin. The process makes Shatdhaut Ghrita less greasy while retaining its moisturizing abilities.

·       Fat-Soluble Vitamins (A, D, E, K): These vitamins are crucial for maintaining healthy skin and are known for their anti-aging, antioxidant, and healing properties.

·       Fatty Acids (Butyrate, Lauric Acid, Linoleic Acid): These fatty acids are integral to moisturizing and nourishing the skin. Butyrate, in particular, has shown promise in reducing inflammation and promoting cell regeneration.

 

2. Properties of Shatdhaut Ghrita for Skin5:

Shatdhaut Ghrita has a number of key properties that make it beneficial for skin care. Its traditional use in Ayurvedic medicine was specifically for skin healing, hydration, and anti-aging.

a)    Deep Moisturization:

Shatdhaut Ghrita, due to its lipid-rich nature, acts as an excellent emollient. It deeply penetrates the skin’s stratum corneum (the outermost skin layer), providing intense moisture without causing a greasy or oily residue. This makes it an excellent choice for individuals with dry skin, as it can lock moisture into the skin for hours. The moisture retention helps maintain skin hydration, preventing dryness and cracking.

b)    Anti-Inflammatory Effects:

Shatdhaut Ghrita is also known for its ability to calm inflammation, making it suitable for conditions like eczema, psoriasis, and rosacea. The ghee’s anti-inflammatory properties help reduce redness, itching, and swelling, which is particularly beneficial for sensitive or irritated skin.

c)     Skin Healing and Repair:

Ghee itself has been used for centuries in Ayurvedic treatments for its skin-repairing and healing properties. The washing process in the preparation of Shatdhaut Ghrita makes it less likely to irritate, but still effective in promoting cell regeneration and repairing damaged skin. It is particularly effective for healing dry, cracked, or sun-damaged skin and for reducing the appearance of scars and blemishes.

d)    Antioxidant and Anti-Aging Properties:

Shatdhaut Ghrita is rich in antioxidants like Vitamin E, which helps neutralize free radicals, thereby reducing oxidative stress on the skin. Free radicals contribute to premature skin aging, so the antioxidant effect of Shatdhaut Ghrita can help protect against wrinkles, fine lines, and other signs of aging. The Vitamin A content in ghee supports collagen production, which is essential for maintaining the skin’s elasticity and firmness.

e)     Non-Comedogenic Nature:

Despite being an oil-based product, Shatdhaut Ghrita is often considered non-comedogenic (does not clog pores). This is a result of the washing process, which reduces the product's tendency to block pores. This makes it suitable for individuals with acne-prone skin or those concerned about breakouts.

 

3. Benefits of Shatdhaut Ghrita in Moisturizing Creams6:

1.   Deep Hydration and Moisturization:

·       Ayurvedic References: In classical Ayurvedic texts, ghee (clarified butter) is described as an essential nutrient for the skin, especially for its moisturizing and rejuvenating properties. According to the Charaka Samhita and Sushruta Samhita, ghee is beneficial for nourishing and hydrating tissues, especially when applied externally.

·       Scientific Insight: Ghee is known to be rich in short-chain and medium-chain fatty acids, which penetrate the skin barrier effectively, helping to hydrate dry and cracked skin. Studies on oils and fats like ghee demonstrate their ability to form protective barriers on the skin, reducing water loss and increasing moisture retention.

 

2.   Nourishing and Rejuvenating Skin:

·       Ayurvedic References: The ancient texts, like Ashtanga Hridaya, mention that ghee is deeply nourishing for both the internal and external tissues. The cleansing process used in making Shatdhaut Ghrita makes it lighter and purer, enhancing its ability to nourish the skin without causing heaviness.

·       Scientific Insight: Research has highlighted that ghee contains fat-soluble vitamins, such as vitamins A, D, E, and K, which are vital for skin regeneration and cell repair . These compounds support collagen production, a key component for skin elasticity and anti-aging benefits.

 

3.   Soothing and Calming Effect:

·       Ayurvedic References: According to Ayurvedic principles, ghee is considered to have a calming effect on the Pitta dosha, which governs heat, irritation, and inflammation in the body. When applied externally, Shatdhaut Ghrita cools and soothes inflamed or sensitive skin.

·       Scientific Insight: Studies show that fatty acids, particularly those in ghee, possess anti-inflammatory properties. Butyrate, a short-chain fatty acid found in ghee, has been linked to reducing skin inflammation and irritation.

 

4.   Improving Skin Texture and Tone:

·       Ayurvedic References: In Ayurveda, ghee is considered a rasayana (rejuvenative) that helps improve the quality of skin by promoting softness and smoothness. The Sushruta Samhita recommends ghee for enhancing skin texture and treating roughness and dryness.

·       Scientific Insight: Ghee’s lipid composition, which includes saturated fatty acids and antioxidants, helps improve skin’s barrier function. Studies have also shown that ghee can provide a smoothing effect by softening keratin, the protein that makes the skin rough.

 

5.   Healing and Repairing Damaged Skin:

·       Ayurvedic References: Ghee’s use in wound healing is well-documented in Ayurveda. Charaka Samhita mentions ghee as a healing agent for burns, cuts, and scars, promoting faster tissue regeneration and minimizing scar formation.

·       Scientific Insight: Ghee is rich in butyrate, which has been shown to aid tissue repair and regeneration. It is believed that butyrate reduces oxidative stress and promotes the healing of skin cells.

 

6.   Antibacterial and Antioxidant Properties7:

·       Ayurvedic References: The antibacterial and antioxidant properties of Shatdhaut Ghrita are recognized in Ayurvedic texts. Ghee is often included in Ayurvedic formulations for treating infections, preventing skin disorders, and maintaining skin health.

·       Scientific Insight: Modern studies show that ghee possesses both antioxidant and antimicrobial properties. The presence of vitamin E (especially alpha-tocopherol) in ghee makes it effective in protecting the skin from free radicals and environmental stressors. Furthermore, its antimicrobial effects are beneficial for preventing acne and other bacterial skin infections.

 

7.   Suitable for All Skin Types8:

·       Ayurvedic References: In Ayurveda, ghee is considered to have a balancing effect on all three doshas (Vata, Pitta, and Kapha). Shatdhaut Ghrita is specifically processed to be less heavy and more balanced for various skin types, including oily and sensitive skin.

·       Scientific Insight: Research has shown that despite being an oil-based product, ghee does not clog pores, making it suitable for oily skin. It is also non-irritating and safe for sensitive skin due to its hypoallergenic nature.

 

8.   Antioxidant and Anti-aging Effects9:

·       Ayurvedic References: The use of ghee for its anti-aging and anti-wrinkle effects is well-established in Ayurvedic beauty treatments. According to the Charaka Samhita, ghee helps to maintain youthful skin and prevents wrinkles and sagging.

·       Scientific Insight: Ghee’s antioxidants, such as vitamin E, help combat oxidative stress, a leading factor in the development of wrinkles and fine lines. Studies on natural oils show that antioxidants play a key role in reducing signs of aging by protecting against UV damage and pollution.

9.   Improves Skin’s Natural Radiance:

·       Ayurvedic References: In Ayurveda, Shatdhaut Ghrita is considered to impart a natural glow to the skin. It nourishes the skin deeply and balances the bodily humors, leading to a radiant complexion.

·       Scientific Insight: The presence of fatty acids and fat-soluble vitamins in Shatdhaut Ghrita aids in improving the skin’s natural radiance by deeply moisturizing and providing essential nutrients to the skin cells. These compounds contribute to a healthy, glowing appearance by reducing skin dullness and dryness.

 

10. Natural Composition and Safety:

·       Ayurvedic References: Shatdhaut Ghrita is considered a safe and gentle ingredient in Ayurvedic formulations. Its purifying process ensures that it is free of impurities and toxins, making it suitable for sensitive skin.

·       Scientific Insight: Modern research supports the use of natural, non-toxic skincare ingredients like ghee, especially for those with sensitive skin or conditions like eczema and dermatitis. Shatdhaut Ghrita, being a natural substance, is less likely to cause irritation or allergic reactions compared to synthetic chemicals found in many skincare products.

 

Shatdhaut Ghrita is a traditional Ayurvedic formulation that involves the repeated washing or churning of ghee (clarified butter) with water. The name "Shatdhaut" means "six times washed," and the process is intended to purify the ghee and enhance its therapeutic properties. It has been used for centuries in Ayurvedic medicine for various purposes, particularly for skin diseases, inflammatory conditions, and as a rejuvenating agent.

 

Preparation: Shatdhaut Ghrita is typically prepared by churning ghee with water, repeating the process up to six times. This practice is believed to purify the ghee, enhancing its ability to balance the doshas (Vata, Pitta, and Kapha) and act as a powerful therapeutic agent for the skin, nervous system, and overall well-being.

 

The preparation process is described as follows10:

1.     Pure ghee is placed in a vessel.

2.     Water (usually pure and clean) is added to the ghee.

3.     The mixture is churned (or beaten) repeatedly, often up to six times.

4.     After each churn, the mixture is separated, and the ghee is collected.

 

Therapeutic Applications: Shatdhaut Ghrita is commonly used in Ayurveda for11:

·       Skin Care: It is considered effective for treating various skin conditions such as eczema, psoriasis, dry skin, and dermatitis. The soothing and moisturizing properties of ghee, combined with the purifying process, make it an excellent emollient for the skin.

·       Wound Healing: The application of Shatdhaut Ghrita to cuts, abrasions, and burns is a traditional remedy.

·       Anti-inflammatory and Rejuvenating: It is used for reducing inflammation and promoting rejuvenation in the body.

·       Balancing Doshas: It is believed to balance all three doshas, especially Pitta, due to its cooling properties.

 

Scientific Support for Shatdhaut Ghrita's Effectiveness12:

The scientific basis for Shatdhaut Ghrita's effectiveness can be explored from multiple perspectives, including the properties of ghee, the process of preparation, and the biochemical effects on skin and health.

 

1. Ghee and Its Properties:

Ghee is rich in saturated fats, including butyric acid, which is known for its anti-inflammatory, antimicrobial, and healing properties. It also contains conjugated linoleic acid (CLA), which has been shown to reduce inflammation and promote wound healing.

Studies on Ghee:

·       Butyric acid in ghee has been shown to have anti-inflammatory effects. highlighted that butyrate (the short-chain fatty acid produced from butyric acid) has a significant anti-inflammatory effect by modulating immune responses and inhibiting pro-inflammatory cytokines.

·       indicated that ghee has antioxidant properties, which could play a role in skin rejuvenation and reducing oxidative stress.

 

2. Purification Process (Shatdhaut Technique):

The process of repeated washing or churning is believed to purify the ghee by eliminating impurities and enhancing its properties. Scientific investigations into this process are still limited, but there is evidence that the purification process can alter the chemical composition of the ghee, making it more beneficial for medicinal purposes. discusses how the purification process in Ayurvedic formulations can increase the bioavailability of certain compounds. For example, ghee that has undergone purification is said to have better absorption and therapeutic effects on the skin and body.

 

3. Effects on Skin and Wound Healing:

Shatdhaut Ghrita is traditionally applied to the skin for its soothing and healing effects. Ghee itself is known for its emollient and moisturizing properties, which can support the skin’s lipid barrier and prevent moisture loss.

 

Scientific Evidence on Skin Care:

·       Skin Hydration: Ghee has been shown to improve skin hydration and elasticity. it was observed that topical application of ghee improves skin hydration and reduces transepidermal water loss.

·       Wound Healing: The application of ghee has been found to enhance wound healing. that butyric acid (present in ghee) accelerates the healing process by promoting the migration of keratinocytes and fibroblasts, which are essential for wound repair.

 

4. Anti-inflammatory and Rejuvenating Properties13:

Shatdhaut Ghrita’s cooling and anti-inflammatory properties are often attributed to the ghee and the purification process. Research has shown that ghee has potent anti-inflammatory properties, which are beneficial for conditions like arthritis, skin inflammation, and autoimmune diseases.

 

Anti-inflammatory Mechanisms:

·       Conjugated Linoleic Acid (CLA): CLA in ghee has been demonstrated to exhibit anti-inflammatory effects This can be beneficial in treating inflammatory skin conditions like eczema and psoriasis.

·       Anti-oxidative Effects: Ghee has antioxidant properties, which help in reducing oxidative stress. Oxidative stress is known to play a major role in skin aging and inflammatory diseases. highlighted that ghee has a high content of antioxidant compounds, which could explain its rejuvenating effects.

 

5. Therapeutic Properties in Ayurvedic Context14:

Ayurveda emphasizes the holistic benefits of Shatdhaut Ghrita for balancing the doshas. From a modern scientific standpoint, its cooling effects, attributed to the process of Shatdhaut, can help reduce Pitta dosha (associated with heat and inflammation). The rejuvenating properties align with the notion of "rasayana" (rejuvenation) in Ayurveda, which seeks to restore vitality and longevity.

1.     Panchagavya and Ghee as Key Ingredients:

·       Ghee is a central component in Ayurveda for its ability to nourish the body and mind, enhance digestion, and balance the doshas (Vata, Pitta, and Kapha).

·       The process of Shatdhaut involves washing the ghee multiple times, which purifies it and enhances its effectiveness, making it capable of reaching deeper tissues when used.

 

2.     Properties of Shatdhaut Ghrita15:

·       Rasayana (Rejuvenative): It is widely recognized for its rejuvenating qualities, which help in promoting longevity, vitality, and overall well-being. The application of Shatdhaut Ghrita in Ayurveda is similar to that of a restorative tonic.

·       Tridosha Balancer: It has a balanced effect on the three doshas—Vata, Pitta, and Kapha. This makes it useful for treating conditions that are the result of dosha imbalances.

·       Vata conditions (such as dry skin, arthritis, anxiety) are soothed by its moisturizing and lubricating properties.

·       Pitta imbalances (such as inflammation, acidity) are reduced due to its cooling and calming effects.

·       Kapha conditions (such as obesity, respiratory issues) are addressed through its digestive and detoxifying properties.

·       Sattvic Quality: It is considered to have a sattvic nature, which is a pure and serene quality. It has a positive impact on the mind, reducing stress, anxiety, and promoting mental clarity.

 

3.     Therapeutic Uses in Ayurveda16:

·       Skin Disorders: It is frequently used in treating various skin diseases, such as eczema, psoriasis, and dermatitis, due to its ability to hydrate and promote healing. When applied topically, Shatdhaut Ghrita works as a moisturizer, providing deep nourishment and acting as an anti-inflammatory agent.

·       Digestive Health: Due to its nourishing and lubricating qualities, Shatdhaut Ghrita is often recommended for improving digestion and absorption. It helps in soothing the digestive tract and promoting better nutrient assimilation. It is useful in treating conditions like constipation and indigestion.

·       Neurological Health: Shatdhaut Ghrita is used to improve mental function, enhance memory, and reduce anxiety. Its application in Brahmi Ghrita and Medhya Rasayana formulations is linked with cognitive enhancement.

·       Detoxification (Purification): Ghee has a cleansing effect on the body, and Shatdhaut Ghrita is used to detoxify and balance the body's internal environment.

·       Joint Health and Inflammation: Shatdhaut Ghrita is effective in reducing inflammation and soothing pain in conditions like arthritis. It can be applied topically or consumed internally for these purposes.

 

4.     Application and Method of Use:

·       External Application: It is applied on the skin to treat various dermatological conditions, such as wounds, burns, and dryness. It can also be used in Abhyanga (oil massage) to improve circulation and detoxify the skin.

·       Internal Consumption: When consumed in prescribed doses, it helps in promoting digestive health, reducing inflammation, and enhancing overall health.

·       Nasal Administration (Nasya): In some cases, it is used for Nasya (nasal administration) for its benefits in improving respiratory health and enhancing brain function.

 

5.     Scientific Perspective:

·       The process of washing ghee multiple times enhances its ability to penetrate deeper layers of tissue. Ayurveda uses Shatdhaut Ghrita as a medium to carry other medicinal ingredients deeper into the body.

·       Ghee itself contains butyrate, which has anti-inflammatory, antioxidant, and anti-cancer properties. The addition of water washing helps in creating a balanced oil that promotes tissue nourishment and hydration without being too greasy.

·       Modern studies on ghee have recognized its ability to support fat-soluble vitamin absorption and its positive effects on immunity and skin health.

 

5. Formulating Moisturizing Creams with Shatdhaut Ghrita17:

When formulating moisturizing creams with Shatdhaut Ghrita, it is important to combine it with other complementary natural ingredients to enhance its effectiveness. Here are a few potential ingredients that can be used in combination:

·       Aloe Vera: Known for its ability to hydrate and soothe irritated skin, aloe vera can complement Shatdhaut Ghrita by enhancing its moisturizing and healing properties.

·       Essential Oils (Lavender, Rose, Chamomile): These oils add fragrance and additional therapeutic benefits, such as antimicrobial, calming, and anti-inflammatory properties.

·       Herbal Additives (Turmeric, Neem): Turmeric provides anti-inflammatory and anti-aging benefits, while neem offers antibacterial and antifungal protection, making the cream more versatile for skin conditions like acne or fungal infections.

 

6.  Challenges and Considerations18:

·       Shelf Life and Stability: Like most natural formulations, Shatdhaut Ghrita has a relatively short shelf life, especially when mixed with water-based ingredients. Proper preservatives must be added to ensure the cream remains stable and does not spoil.

·       Allergies and Sensitivities: Although Shatdhaut Ghrita is generally well-tolerated, individuals with dairy allergies or sensitivities should perform patch tests before use to rule out adverse reactions.

 

CONCLUSION:

Shatdhaut Ghrita, with its deep moisturizing, anti-inflammatory, antioxidant, and skin-healing properties, is an exceptional base for moisturizing creams. Its gentle and effective formulation makes it suitable for a wide range of skin types, especially dry, sensitive, and aging skin. Combined with other natural ingredients, it can provide a holistic and effective skincare solution that nourishes, hydrates, and protects the skin. Modern research corroborates many of the traditional benefits of Shatdhaut Ghrita, making it a scientifically-backed ingredient in contemporary skincare formulations. By incorporating Shatdhaut Ghrita into cosmetic creams, manufacturers can offer a natural, Ayurvedic solution to modern skin concerns, tapping into the growing demand for sustainable and effective skincare products.

 

REFERENCES:

1.      Sharma PV. Classical Uses of Medicinal Plants. 1st ed. Chaukhambha Visvabharati. 2004. p. 120-25.

2.      Dash B, Kashyap L. Materia Medica of Ayurveda. 1st ed. New Delhi: Concept Publishing; 2001.

3.      Patwardhan B, Vaidya A, Chorghade M. Ayurveda and natural products drug discovery. Curr Sci. 2004; 86(6): 789-99.

4.      Mukherjee PK, Rai S, Bhattacharyya S, et al. Clinical validation of Ayurvedic products. Phytomedicine. 2017; 34: 152-65.

5.      Jaiswal Y, Liang Z, Ho A. Chemical profiling of medicinal oils. J Ethnopharmacol. 2016; 189: 226-37.

6.      Kumar N, Neelam. Role of clarified butter in wound healing. Ayurveda J. 2018; 12(3): 197-204.

7.      Gogte V. Ayurvedic Pharmacology and Therapeutic Uses of Medicinal Plants. 1st ed. Mumbai: Chaukhambha Sanskrit Pratishthan; 2006.

8.      Singh BB, Vinjamury SP, Der-Martirosian C. Herbal oil in skincare: Evidence from Ayurveda. Complement Health Pract Rev. 2008; 13(1): 13-31.

9.      Varier PS. Indian Medicinal Plants: A Compendium of 500 Species. 3rd ed. Arya Vaidya Sala Kottakkal; 1995.

10.   Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. New Delhi: CSIR; 1956.

11.   Pandey G, Prasad Basu A. Anti-inflammatory and skin-protective properties of herbal oils. Int J Dermatol Res. 2014; 12(7): 67-74.

12.   Singh V, Chaudhary AK. Traditional uses of medicinal plants in skin diseases. Ethnobot Res Appl. 2011; 9: 153-60.

13.   Subramaniam S, Krishnan V. Physicochemical properties of ghee as a formulation base. Int J Dairy Sci. 2019; 14(4): 110-5.

14.   Kumar A, Singh D. A review on ayurvedic skincare applications. Ayurveda Int J. 2020; 23(2): 44-50.

15.   Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers; 2018.

16.   Khalsa KP. Ayurvedic Dermatology and Skincare. New York: Elsevier; 2017.

17.   Ayurveda Formulary of India. Part 1. Ministry of Health and Family Welfare, Government of India; 2003.

18.   Pandit S, Mishra SK. Herbal formulations for moisturizing properties: A comparative study. J Herb Med. 2021; 29: 100465.

19.   Aggarwal BB, Prasad S. Oil-based therapeutics: A comparative insight. Phytother Res. 2015;29(1):17-23.

20.   Kumar R, Mishra A. Topical applications of Ayurvedic oils for skincare. Clin Dermatol. 2018; 36(3): 279-87.

21.   Avish D. Maru, Rajendra K. Surawase, Prashant V. Bodhe. Development and Evaluation of Moisturizing Cream Containing Rice Bran Wax. Res. J. Topical and Cosmetic Sci. 2012; 3(1): 40-44.

22.   Rabindra K Nanda, Amol A Kulkarni, Meenal N Ranjane, Poonam N. Ranjane. A Stability-indicating HPTLC method for estimation of Nadifloxacin in topical cream. Res. J. Topical and Cosmetic Sci. 2010; 1(1): 25-29.

23.   Pruthviraj S Pawar, Prajakta P Karpe, Prabhakar Jadhav, Atul Alkunte, Patil SM. Pre-Formulation and Evaluation of Herbo-Mineral Ointment and Cream. Res. J. Topical and Cosmetic Sci. 2010; 1(1): 30-32.

24.   Ram Kumar Sahu, Amit Roy, Pradeep Kushwah, Ashmita Sahu. Formulation and development of face cream containing natural products. Res. J. Topical and Cosmetic Sci. 2012; 3(1): 16-19.

25.   Avish D. Maru, Rajendra K. Surawase, Prashant V. Bodhe. Development and Evaluation of Moisturizing Cream Containing Rice Bran Wax. Res. J. Topical and Cosmetic Sci. 2012; 3(1): 40-44.

26.   Ankush Sharma, Bharat Prasar. Formulation and Evaluation of herbal cosmetic cream to produce multipurpose effect on skin. Res. J. Topical and Cosmetic Sci. 2013; 4(1): 1-4.

27.   Seema V. Pattewar, Deepak N. Patil. Formulation of herbal antibacterial cream by using extract from Kalanchoe pinnata leaves. Research J. Topical and Cosmetic Sci. 2014; 5(1): 1-4.

28.   Amit Roy, Ram Kumar Sahu. Formulation and Development of Herbal Sunscreen Cream. Research J. Topical and Cosmetic Sci. 2014; 5(1): 12-14.

29.   Gurubarik Neelima, Saroj Kumar Raul, Jami Kranthi, Saravakota Sandeep. Formulation and Evaluation of Sun Protection Factor of Poly Herbal Sunscreen Cream. Research J. Topical and Cosmetic Sci. 2016; 7(1): 09-14.

30.   Saikrishna Reddy, Akshaya Reddy, Pranitha, Sravani, Kvm Krishna, A. Ramesh. A Short Review on Targeted Novel Cream. Research J. Topical and Cosmetic Sci. 2016; 7(1): 19-22.

31.   Priya R. Kawarkhe, Subhash V. Deshmane, Kailash R. Biyani. Formulation and Evaluation of Antioxidant Face Cream Containing Raspberry Fruit and Grape Seeds Extract. Research J. Topical and Cosmetic Sci. 2016; 7(2): 73-78.

32.   R. Chandrasekar, B. Sivagami. Formulation and Evaluation of a Poly Herbal Skin Care Cream containing Neem and Tulsi. Research J. Topical and Cosmetic Sci. 2018; 9(1): 25-32.

 

 

Received on 05.01.2025      Revised on 23.01.2025

Accepted on 07.02.2025      Published on 03.03.2025

Available online from March 10, 2025

Res.  J. Pharma. Dosage Forms and Tech.2025; 17(1):19-25.

DOI: 10.52711/0975-4377.2025.00003

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