A Recent attempt made on Fast Disintegrating Tablets: A Precise Review
Hindustan Abdul Ahad, Haranath Chinthaginjala, Nagarajugari Kavyasree,
Jyothi Vinay Krishna, Sushma Papireddypalli, Kotlo Saijyoshna
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research
(RIPER) - Autonomous, K.R. Palli Cross, Chiyyedu (P), Ananthapuramu - 515721, AP, India.
*Corresponding Author E-mail: drabdulriperatp@gmail.com
ABSTRACT:
The purpose of this study was to investigate previous research on fast-acting pills. Fast dissolving tablets (FDTs) have become a rapidly emerging field in the pharmaceutical business over the last ten years. For the administration of many medications, oral drug delivery remains the recommended method. Scientists have developed FDTs with increased patient compliance and convenience during insertion into the mouth because of recent technological advances. For simple administration of active pharmaceutical substances, these tablets crumble or dissolve in the mouth without the use of water. Because of the formulation's popularity and use, several FDT technologies have been developed. FDTs are solid unit dosage forms that dissolve or disintegrate quickly in the mouth without the use of water or chewing. FDT shines in areas where pediatrics and geriatrics have trouble swallowing traditional tablets and capsules. FDT is a new drug delivery system that is intended for rapid dissolution and action, as well as treating acute illnesses with greater patient compliance. The authors gathered enough data from previous FDT trials. This review article can be used by researchers to quickly obtain latest literature on FDT.
KEYWORDS: Disintegrating, Literature, Mouth dissolving, Past work, Polymers.
INTRODUCTION:
There are several ways in which drugs can be delivered by oral solids in indefinite quantities (tablets and capsules). Despite a hundred years of development, they are made in an extremely non-sterile environment and the process, instruments, and technology are well defined and acknowledged. Due to the high volume of goods produced in these indefinite quantity forms, it is essential that the unit operations for his or her production be fully understood, developed, and implemented.
Because oral dosage forms are simple and convenient to use, they are preferred over other dosage forms. There are many types of drugs available by prescription and in a wide range of dosage forms1.
A strategic drug delivery method extends a product's lifecycle. Orally administered dosages are estimated to account for 50-60% of total doses. It is the most common way used for general effect due to its convenience of administration, discomfort, variety, and low patient compliance. Solid dosage forms can be dissolved in water and swallowed, or chewed, or quickly dissolved in the mouth. A normal way of swallowing dosage forms involves placing them in the mouth, allowing them to dissolve in saliva, and swallowing them. The active ingredient with the bitterest taste, quick dissolution, quick absorption on site, and quick action. Often called mouth dissolving tablets or melt-in-mouth dissolving tablets, FDT liquify rapidly in the aperture. When rap melts into porosity, FDT liquify rapidly2. A fast-dissolving tablet dissolves or disintegrates in the aperture lacking requiring water. There are some tablets that dissolve rapidly in saliva and are called "true fast-dissolving" tablets. Solid dosage forms that liquify rapidly in the mouth can be described as FDT3-5.
The advantages of MDT:
The merits of MDT are highlighted here6
· The tablets can be swallowed without water.
· A child, an elderly person, or someone with mental disabilities can easily take this medicine.
· Liquids do not provide accurate dosing.
· The use of flavours and sweeteners results in an excellent mouth feel.
· This product can be administered during travel without the need for water.
The past attempts made on mouth dissolving/disintegrating tablets were as illustrated in table 1.
Table 1: Recent attempts made on mouth dissolving tablets
|
Drug Name |
Polymer |
Reference |
|
Valdecoxib |
Polyvinyl Pyrrolidone (PVP), Sodium Carboxy Methyl Cellulose (SCMC), Crospovidone (CP) and β-Cyclodextrin |
7Gnanaprakash et al., 2009 |
|
Aceclofenac |
SSG (sodium starch glycolate) |
8Bhardwaj et al., 2010 |
|
Levocitirizine |
Hydroxypropylmethylcellulose (HPMC) and polyvinyl alcohol (PVA) |
9Prabhu et al.,2010 |
|
Chlorpromazine HCL |
HPMC, CP, SSG and PVP |
10kumar Gudas et al.,2010 |
|
Cinnarizine |
croscarmellose sodium (CCS) and SSG |
11Basu et al., 2011 |
|
Promethazine HCl |
SSG and CCS |
12Kavitha et al., 2011 |
|
Cinnarizine |
SSG and CCS |
13Siraj et al., 2011 |
|
Tramadol HCl |
CP, SSG and CCS |
14Patil et al., 2011 |
|
Felodipine |
CCS, SSG and CP |
15Kumar et al., 2012 |
|
Ondansetron HCl |
Kyron t-134 |
16Remya et al.,2012 |
|
Lamivudine |
CCS, SSG and CP |
17Sathali et al.,2012 |
|
Amlodipine besylate |
HPMC and SSG |
18Sukhavasi et al.,2012 |
|
Telmisartan |
CCS, and SSG |
19Dhiman et al., 2012 |
|
Albendazole |
MCS |
20Rane et al., 2012 |
|
Losartan potassium |
PVA and Maltodextrin |
21Bansal et al., 2013 |
|
Metoprolol tartrate |
SSG, CCS and CP |
22Satpute et al., 2013 |
|
Telmisartan |
SSG and CCS |
23Chauhan et al., 2013 |
|
Amoxicillin trihydrate |
SSG and CCS |
24Saroha et al., 2013 |
|
Diclofenac sodium |
SSG and CCS |
25Damodar et al., 2014 |
|
Eletriptan HBr |
SSG and CCS |
26Pingale et al., 2014 |
|
Neviraine |
SSG and CCS |
27Kola et al., 2014 |
|
Silymarin |
CCS |
28Saini et al., 2014 |
|
Atenolol and atorvastatin |
CCS and Kyron-T134 |
29Sarfraz et al., 2015 |
|
Metformin |
CCS and CP |
30Haque et al., 2015 |
|
Hydrochlorothiazide |
CCS and CP |
31Soni et al., 2015 |
|
Furosemide |
CP, CCM and SSG |
32Ibrahim et al., 2017 |
|
Chlorpheniramine maleate |
SSG and CCS |
33Dave et al.,2017 |
|
Carvedilol |
HPMC |
34Kharde et al., 2018 |
|
Ketoprofen |
CCS and CP |
35Saif et al., 2018 |
|
Ketoprofen |
PVP |
36Muralidhar et al.,2019 |
|
Atenolol |
CCS and SSG |
37Mane et al., 2019 |
Montelukast |
SSG and mannitol |
39Kumar et al.,2019 |
Salbutamol sulphate |
HPMC |
40Nurhabibah et al., 2019 |
Febuxostat |
CP |
41Kaur et al., 2020 |
Chlorpheniramine Maleate |
SSG and CCS |
42Malang et al., 2020 |
Pantoprazole |
CCS, SSG and CP |
43Shrilatha et al., 2020 |
Paracetamol |
CCS and SSG |
44Malang et al., 2020 |
Acetaminophen |
SSG and CCS |
45Eraga et al., 2020 |
Piroxicam |
PVP |
46Gowthamy et al., 2020 |
Pitavastatin |
SSG, CCS and CP |
47Teaima et al., 2021 |
Flurbiprofen |
SSG and CP |
48Mushtaq et al., 2021 |
Domperidone |
Chitosan-glycine |
49Singh et al., 2021 |
Captopril |
CP and SSG |
50Ingale et al., 2021 |
Lansoprazole |
SSG, CP and CCS |
51Choursiya et al., 2021 |
Benzepril HCl |
SSG, CCS and CP |
52Bhargava et al., 2021 |
Ketorolac tromethamine |
CCS, CP and SSG |
53Bindal et al., 2021 |
Atorvastatin |
SSG and CCS |
54Rao et al., 2021 |
Domperdone |
Pectin, Pullulan, and Karaya Gum |
55Thorat et al., 2021 |
Furosemide |
SSG, CCS and CP |
56Khadka et al., 2021 |
CONCLUSION:
The authors summaries the findings of this study based on previous research on Fast dissolving tablets conducted over the last decade. The authors gathered sufficient data from previous Fast dissolving tablet research. Researchers can use this literature review to obtain the latest information on fast dissolving tablets.
ACKNOWLEDGMENT:
The authors are thankful to the department of industrial pharmacy of RIPER for the encouragement and support.
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Received on 29.01.2022 Modified on 24.02.2022
Accepted on 20.03.2022 ©AandV Publications All Right Reserved
Res. J. Pharma. Dosage Forms and Tech.2022; 14(3):229-232.
DOI: 10.52711/0975-4377.2022.00037