Volume No. :   11

Issue No. :  4

Year :  2019

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Healing effect of Spray gel collagen extract from Channa striata bone on burn in rats



Address:   Amallia Rachmasari, Rafidha Aisyah Kartini, Gita Alviani, Indah Solihah*
Department of Pharmacy, Sriwijaya University, Inderalaya 30662, South Sumatera, Indonesia
*Corresponding Author
DOI No: 10.5958/0975-4377.2019.00046.6

ABSTRACT:
The aims of this study was to investigate the healing effect of spray gel collagen extract from Channa striata wastes bones in a deep second-degree burn model in rats. Collagen extraction was used acid soluble collagen (ASC) method. Spray gel collagen extract was used Carbopol® 940 and HPMC-60SH as gelling agent. The quality control of spray gel collagen extract was evaluated for physical appearance, adhesive strength, pH, viscosity, pump delivery, and spray pattern. The in vivo study was used 24 adults, male Wistar-albino rats, divided into 4 groups. The first was normal saline (NS) groups as negative control. The second was base spray gel (BSG) group as placebo. The third was Bioplacenton® group as positive control. And the last was spray gel collagen extract (SCE) group as treatment group. The percentage of wound contraction was observed every 2 days for 14 days, followed by observation in the period of epithelialization of the wound. Collagen extraction with ASC method has 1.927,14±4,76 ppm of total protein. The results of quality control of SCE meets all standard value for gel preparation. Furthermore, the result of in vivo study showed that SCE group has the best rate of burn wound healing among all control groups, and significantly better than NS and BSG groups. In conclusion, application of SCE is effective in healing burn-related skin wounds in the rat model as well as Bioplacenton® gel.
KEYWORDS:
Channa striata, collagen, spray gel, burn wound, rat.
Cite:
Amallia Rachmasari, Rafidha Aisyah Kartini, Gita Alviani, Indah Solihah. Healing effect of Spray gel collagen extract from Channa striata bone on burn in rats. Res. J. Pharma. Dosage Forms and Tech.2019; 11(4):275-279.
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