Volume No. :   10

Issue No. :  3

Year :  2018

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Self-Emulsifying Drug Delivery System



Address:   Dhanashree R. Karade, Nivedita H. Patil, Dr. P. J. Shirote, Mrs. Bhavana Deshmane
Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, South Shivajinagar, Miraj Road, Sangali, PIN-416416, Dist.-Sangli, Maharashtra, India.
*Corresponding Author
DOI No: 10.5958/0975-4377.2018.00031.9

ABSTRACT:
Nowadays, nearly 35-40% of new drug candidates have poor water solubility. Oral delivery of such drugs is associated with the problem of low bioavailability. To overcome these issues various formulation strategies have been exploited. Advanced approaches include self-emulsifying drug delivery system (SEDDS). Different formulation strategies such as the use of surfactants, lipids, permeation enhancers, micronization, salt formulation, cyclodextrins, nanoparticles and solid dispersions are now being used to overcome these problems. The absorption and availability of the drug can be enhanced by solubilising self the drug within a colloidal dispersion. Physically stable formulations such as lipid solutions, emulsions and emulsion pre-concentrates are more popular and suitable for encapsulation of poorly soluble drugs. It is focused on lipid-based formulations to improve the oral bioavailability of poorly soluble drugs .In fact, the most popular approach is the incorporation of the drug compound into inert lipid vehicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions and liposomes with particular emphasis on SEDDS. In this review effort was made to give a general idea about the SEDDS. This knowledge may useful for researcher for developing new drug delivery system. These preparations can be given as soft or hard gelatin capsules for easy administration and precise dosage.
KEYWORDS:
Emulsification, self-emulsifying drug delivery system, bioavalibility, solvent surfactant.
Cite:
Dhanashree R. Karade, Nivedita H. Patil, Dr. P. J. Shirote, Mrs. Bhavana Deshmane. Self-Emulsifying Drug Delivery System. Res. J. Pharma. Dosage Forms and Tech.2018; 10(3):200-206.
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