Volume No. :   9

Issue No. :  2

Year :  2017

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Formulation and Evaluation of Sustained Release Matrix Tablets Containing Aceclofenac and Paracetamol



Address:   Hamid Khan1*, Javed Ali2
1JK College of Pharmacy, Bilaspur, CG, India-495001
2Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi, India-110062
*Corresponding Author
DOI No: 10.5958/0975-4377.2017.00010.6

ABSTRACT:
The sustained release matrix tablets were formulated and evaluated by wet granulation method. Tablets were formulated using hydrophilic polymer and binder, HPMC K100 and PVP respectively. In-vitro drug release studies were carried out in hydrochloric acid buffer of pH 1.2 (0.1N) with 1% w/v SLS using USP paddle apparatus. The amount of drugs released at different time intervals were determined by validated UPLC-PDA method. In-vitro drug release from prepared tablets showed better sustained release effect when compared with marketed combination tablets. Tablets thus formulated provided extended release of aceclofenac and paracetamol over the period of 6 h.
KEYWORDS:
Aceclofenac, Paracetamol, Sustained Release, Matrix Tablets, HPMC.
Cite:
Hamid Khan, Javed Ali. Formulation and Evaluation of Sustained Release Matrix Tablets Containing Aceclofenac and Paracetamol. Res. J. Pharm. Dosage Form. & Tech. 2017; 9(2): 48-52.
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