Volume No. :   9

Issue No. :  1

Year :  2017

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Influence of Different Beverages on Disintegration Behavior of Pain Reliever Immediate Release Formulations



Address:   Hardik B. Rana*, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi
Department of Pharmaceutics, Anand Pharmacy College, Anand - 388 001, Gujarat, India
*Corresponding Author
DOI No: 10.5958/0975-4377.2017.00006.4

ABSTRACT:
The objective of the present study was to assess the influence of different beverages like Coco-cola, Orange juice, butter milk, 6% fat and 5% fat containing milk on three immediate release pain reliever tablets of Nimesulide, Mefanamic acid and Aceclofenac. The study was performed in USP disintegration apparatus using different gastric simulated media at 37±0.5 ºC. A hybrid medium of different beverages (640 ml) with 0.1 N HCl (140 ml) was prepared to mimic in vivo condition. The result shown that disintegration time was increased in milk, buttermilk and orange juice and decreased in Coca cola compared to 0.1 N HCl. As the viscosity of fluid increses, the disintegration time was also increased. Coco-cola which contains Carbon Dioxide which was reduce the disintegration time of formulation. From the above study it can be concluded that there is variation in disintegration time of different formulations in different beverages. The patient on these medications should be advised against consuming different beverages with medications because it will affect bioavailability of mediation.
KEYWORDS:
In vitro disintegration, Hybrid Media, Beverages, Pain reliever medications.
Cite:
Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi. Influence of Different Beverages on Disintegration Behavior of Pain Reliever Immediate Release Formulations. Res. J. Pharm. Dosage Form. & Tech. 9(1): Jan.-Mar. 2017; Page 29-32.
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