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Research Journal of Pharmaceutical Dosage Forms and Technology
ISSN: 0975-4377(Online), 0975-234X(Print)
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In vitro Dissolution Studies on Commercial Brands Containing Immediate Release Pioglitazone and Metformin Hydrochloride Extended Release Tablets
K. Soumya*, S. Susanna, T.E.G.K. Murthy
Dept. of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur, Andhra Pradesh, India.
The Quality control (QC) tests like weight variation, hardness, friability, drug content, and Invitro dissolution studies were performed for three commercially available brands containing the combination of two anti diabetic drug pioglitazone (15mg) and metformin (500mg) hydrochloride. The dissolution studies were performed in 0.1N hydrochloric acid (pioglitazone HCl) up to 45 minutes and in 6.8phosphate buffer (metformin HCl) up to 10hours. The selected formulations satisfied QC requirements. A significant difference in dissolution parameters were noticed from the above brands. The drug dissolution from pioglitazone and metformin hydrochloride marked brand followed first order kinetics and zero order kinetics respectively.
Pioglitazone Metformin combination comparative Invitro dissolution studies .
K. Soumya, S. Susanna, T.E.G.K. Murthy. In vitro Dissolution Studies on Commercial Brands Containing Immediate Release Pioglitazone and Metformin Hydrochloride Extended Release Tablets. Res. J. Pharm. Dosage Form. & Tech. 9(1): Jan.-Mar. 2017; Page 15-18.
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