Volume No. :   8

Issue No. :  4

Year :  2016

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Determination of Effect of pH, Temperature and RPM on dissolution of Telmisartan by Two Factorial Design



Address:   Sheema Nafees. S*, Sayad Basha. K , Thirumalesh S.B
Department of Pharmaceutics, JNTUA - Oil Technological Research Institute, Ananthapuram, A.P, India.
*Corresponding Author
DOI No: 10.5958/0975-4377.2016.00038.0

ABSTRACT:
The main intend of present study was to determine how the dissolution parameters such as rpm, temperature and pH affects drug release for the marketed Telmisartan IR tablets. They were quantitatively and statistically studied by applying two factorial design. The dissolution parameters like temperature of the medium, pH of the medium and rpm were taken from low level to high levels and factorial design was applied at -1,+1 levels. The experiment was performed and drug release was estimated. Factorial design proved, the drug release up to 90% within 30 min. Finally, change in pH was found to be having more prominent effect on drug release than temperature and rpm.
KEYWORDS:
Dissolution, Temperature, RPM, pH , Factorial Design
Cite:
Sheema Nafees. S, Sayad Basha. K , Thirumalesh S.B. Determination of Effect of pH, Temperature and RPM on dissolution of Telmisartan by Two Factorial Design. Res. J. Pharm. Dosage Form. & Tech. 2016; 8(4): 273-276.
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