Volume No. :   8

Issue No. :  2

Year :  2016

ISSN Print :  0975-234X

ISSN Online :  0975-4377


Registration

Allready Registrered
Click to Login

Formulation and Evaluation of Diclofenac Suspension by Using Natural Suspending Agents



Address:   Sayad Basha.K*, Sheema Nafees. S, Nethravani. G, Thirumalesh Naik S.B
Department of Pharmaceutics, JNTUA- Oil Technological Research Institute, Ananthapuram, A.P, India
. *Corresponding Author
DOI No: 10.5958/0975-4377.2016.00015.X

ABSTRACT:
The purpose of this study is to search for cheap and effective natural excipients that can be used as an effective alternative for the formulation of pharmaceutical suspensions. In this research natural suspending agents were selected for the study. Gum acacia, compound tragacanth powder and starch were used. The pharmaceutical oral suspensions were prepared by using diclofenac as a model drug by using potassium chloride as flocculating agent. Diclofenac suspensions were prepared with different concentrations (2%, 3%, and 4%w/v) of each suspending agents like compound tragacanth powder, gum acacia and starch. Characterizations of the suspensions were carried out for sedimentation volume, degree of redispersibility, pH, viscosity and flow rate. As per the obtained results, compound tragacanth powder possesses better characteristics as a suspending agent compared to all other natural suspending agents. The results showed that sedimentation volume and viscosity were found to be directly proportional to the concentration of the suspending agents. The compound tragacanth powder was found to have a promising potential for use as a suspending agent in a concentration range of 2-4%w/v.
KEYWORDS:
Gum acacia, starch, redispersibility, sedimentation volume, Tragacanth powder
Cite:
Sayad Basha.K, Sheema Nafees. S, Nethravani. G, Thirumalesh Naik S.B. Formulation and Evaluation of Diclofenac Suspension by Using Natural Suspending Agents. Res. J. Pharm. Dosage Form. and Tech. 2016; 8(2):119-121.
[View HTML]      [View PDF]



Visitor's No. :   149598