Volume No. :   7

Issue No. :  3

Year :  2015

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Elimination of bitter, disgusting taste of Levocetrizine di hydrochloride by HP β –Cyclodextrin



Address:   Durga Devi. K.N1*, N. Narasimha Rao2, K. Geeta Priyanka1, K. Naga Deepika1, G. Venkata Mounika1
1KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India. 2TIL Healthcare, Sricity- SEZ, India.
*Corresponding Author
DOI No: 10.5958/0975-4377.2015.00031.2

ABSTRACT:
Levocetrizine Di Hydrochloride is second generation piperazine derivative, a potent H1 selective anti -histaminic or anti- allergic agent. It has bitter taste. So, the taste has to be masked in order to reduce its bitterness, to increase its palatability and to improve patient compliance. The purpose of this research work to prepare tasteless complexes of levocetrizine di hydrochloride. Conventional taste masking techniques such as use of sweeteners and amino acids and flavoring agents often are unsuccessful in masking the taste of highly bitter drugs. The purpose of this research was to mask the intensely bitter taste of Levocetrizine Di Hydrochloride adopting inclusion complex formation array using HP ß -cyclodextrin by Kneading method. The study conclusively demonstrated the complete masking of bitter taste of Levocetrizine Di Hydrochloride with HP Beta cyclodextrin in 1:1 Kneaded ratio.
KEYWORDS:
anti –histaminic, Kneading method, HP β –cyclodextrin, palatability.
Cite:
Durga Devi. K.N, N. Narasimha Rao, K. Geeta Priyanka, K. Naga Deepika, G. Venkata Mounika. Elimination of bitter, disgusting taste of Levocetrizine di hydrochloride by HP β –Cyclodextrin. Res. J. Pharm. Dosage Form. & Tech. 7(3): July-Sept., 2015; Page 212-214.
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