Volume No. :   7

Issue No. :  2

Year :  2015

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Wound Healing Activity of Poly Herbal formulation



Address:   Syed Safiullah Ghori1* , Mohammed Gouse2, Niranjan Panda3, Shaik Khaled1, Syed Basheeruddin1, Mirza Danish Baig1, Mohammed Yaqub1, Mohammed Mufaqqum1, Arfa Nazneen1, Amtul Zehra Butul1
1Pharmacology Research Lab, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad 50001, Telangana, India
2Almocare Herbal and Ayurvedic Clinic, Chirag Ali lane, Abids, Hyderabad, Telangana, India
3Department of Pharmaceutics, Anwarululoom College of Pharmacy, New Mallepally, Hyderabad 50001, Telangana, India
*Corresponding Author
DOI No: 10.5958/0975-4377.2015.00018.X

ABSTRACT:
Aim: To evaluate the Wound healing potential of a Poly herbal formulation. Material and Methods: In the present work a poly herbal Unani formulation; beeswax (base), sesame oil (10%), olive oil (10%), honey (20%), psoraleac (5%), borax (10%), arnica (5%) and curcuma longa (1%) were used and the wound healing potential was determined by both excision and incision wound healing models. Albino wistar rats were used for this purpose. The wound area in excision wound model and tensile strength in incision wound model were determined. Histopathological studies were also carried out to determine the phases of wound healing. Results: From the results obtained it was evident that the PUF has shown wound healing activity in both excision and incision wound models. In the EWM the beneficial effect of the PUF was evident from the day of first measurement as the progressive decrease in wound area was observed. On the 2nd day of wounding, the wound area shrinkage in 10% formulation treated group was more when compared to the other test groups. The wound area was decreasing constantly and predominantly in all test treated groups as compared to the negative control group. In the IWM there was decrease in tensile strength of the animals treated with the 10% formulation and was comparable with the standard group. In the histopathological examination, the phases in the wound healing process were observed and it showed that proliferation phase was the predominant stage of action of PUF. The best re-modeling, particularly, re-epithelization were detected with the 10% formulation group On the other hand; faster keratinization characterized with minor intraepithelial cornification was seen in 15% group.
KEYWORDS:
Poly herbal Unani formulation (PUF), Excision wound model (EWM), Incision wound model (IWM)
Cite:
Syed Safiullah Ghori , Mohammed Gouse, Niranjan Panda, Shaik Khaled, Syed Basheeruddin, Mirza Danish Baig, Mohammed Yaqub, Mohammed Mufaqqum, Arfa Nazneen, Amtul Zehra Butul. Wound Healing Activity of Poly Herbal formulation. Res. J. Pharm. Dosage Form. & Tech. 7(2): April-June, 2015; Page 125-128.
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