Volume No. :   7

Issue No. :  2

Year :  2015

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Formulation and Evaluation of Fast Dissolving Tablets of Cefixime Trihydrate



Address:   Kamal Arora1, Ish Grover2*, Amit Chandna3, Manish Devgan2
1Research Scholar, Doon Valley Institute of Pharmacy and Medicine, Karnal, Haryana, India.
2Faculty of Pharmacy, RPIIT Technical and Medical Campus, Karnal, Haryana, India,
3Faculty of Pharmacy, Doon Valley Institute of Pharmacy and Medicine, Karnal, Haryana, India.
*Corresponding Author
DOI No: 10.5958/0975-4377.2015.00017.8

ABSTRACT:
Fast Dissolving Tablet instead of dissolving or disintegrating in water is expected to dissolve or disintegrate in oral cavity without drinking water. Super disintegrates are added to a drug formulation to facilitate the break-up or disintegration of tablet or capsule content into smaller particles that can dissolve more rapidly than in the absence of disintegrates In the present study, the effects of a natural superdisintegrants Plantago ovata, Hibiscus rosa sinensis and synthetic superdisintegrants like sodium starch glycolate (SSG), Crosspovidone and Croscarmellose sodium (Ac-di-sol) were compared in the formulations of fast dissolving tablets (FDT). FDTs of Cefixime were prepared by direct compression method and were evaluated for weight variation, hardness, thickness, disintegration time, wetting time, water absorption ratio, In vitro dispersion, friability and dissolution. Among all the super disintegrates, Plantago ovata showed the highest swelling index and natural super disintegrates like husk of Plantago ovata showed better disintegrating property than the most widely used synthetic super disintegrates like AC-di-Sol, C.P and SSG in the formulations.
KEYWORDS:
Disintegration, Superdisintegrants, Fast dissolving tablets, swelling index
Cite:
Kamal Arora, Ish Grover, Amit Chandna, Manish Devgan. Formulation and Evaluation of Fast Dissolving Tablets of Cefixime Trihydrate. Res. J. Pharm. Dosage Form. & Tech. 7(2): April-June, 2015; Page 118-124.
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