Volume No. :   7

Issue No. :  1

Year :  2015

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Antihyperlipidemic Effect of Polyherbal Formulation (PHF) in High Fat Diet Induced Hyperlipidemia



Address:   Nitin Mahurkar1, S.M Sayeed ul hasan2*, S. Mutaal Quadri
1Department of Pharmacology, HKES’s College of Pharmacy, Gulbarga, Karnataka, India
2Department of Pharmacology, MAK College of Pharmacy, Moinabad, Andhra Pradesh, India
*Corresponding Author
DOI No: 10.5958/0975-4377.2015.00003.8

ABSTRACT:
The present study was undertaken to design and assess the influence of polyherbal formulation (PHF) on lipid profile in hyperlipidemic rats. The chronic hyperlipidemia was induced in wistar albino rats of either sex using high fat diet i.e. mixture of coconut oil and vanaspati ghee (2:3 v/v). The rats were fed with high fat diet for a period of 08 consecutive weeks. After the treatment with PHF, the following biochemical parameters were evaluated - serum total cholesterol, triglycerides, low density lipo-protein cholesterol (LDL), very low density lipo-protein cholesterol (VLDL) and serum high density lipo-protein cholesterol (HDL). The treatment with PHF (100 and 200mg/kg, p.o.) significantly reduced the hyperlipidemia, by decreasing the levels of total serum cholesterol, LDL, VLDL and by increasing the HDL in a dose dependent manner, when compared to the control vehicle and standard drug Atorvastatin. The results demonstrated that the PHF possess significant antihyperlipidemic activity.
KEYWORDS:
Hyperlipidemia, High fat diet, Polyherbal formulation.
Cite:
Nitin Mahurkar, S.M Sayeed ul hasan, S. Mutaal Quadri. Antihyperlipidemic Effect of Polyherbal Formulation (PHF) in High Fat Diet Induced Hyperlipidemia. Res. J. Pharm. Dosage Form. & Tech. 7(1): Jan.-Mar. 2015; Page 11-14.
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