Volume No. :   7

Issue No. :  1

Year :  2015

ISSN Print :  0975-234X

ISSN Online :  0975-4377


Registration

Allready Registrered
Click to Login

Influence of Casting Solvent and Polymer on Permeability of Propranolol Hydrochloride Through Eudragit RL100 and Eudragit RLPO Films



Address:   B. Soujanya1*, J. Geethanjali2, D. Mounika3, V. Saikishore4
1Research Scholar, Bapatla College of Pharmacy, Bapatla.
2Department of Analysis, Bapatla College of Pharmacy, Bapatla.
3Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla.
4Associate Professor, Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, India
*Corresponding Author
DOI No: 10.5958/0975-4377.2015.00010.5

ABSTRACT:
In the present work, eudragitL100and Eudragit RLPO films were prepared and evaluated as rate controlling membrane for transdermal drug delivery systems. Dibutyl phthalate or propylene glycol at a concentration of 15w/w of the polymer was used as a plasticizer in the preparation of eudragitL100and Eudragit RLPO films. Casting on mercury surface technique was employed for preparation of eudragitL100and Eudragit RLPO films. The dry films were evaluated for physical appearance, water vapour transmission, drug diffusion and permeability coefficient. Both water vapour transmissions, drug diffusion rate followed zero-order kinetics. The mechanism of drug release was governed by peppas model. The diffusion exponent of release profiles (slope) has a value of1.056-1.071 (n>1), which indicates super case ? transport diffusion. The results obtained in the present study thus indicate that the polymer and solvents used in the preparation of films have shown significant influence on the water vapour transmission, drug diffusion and permeability of the films.
KEYWORDS:
Polymer, solvents, water vapour transmission, drug diffusion and permeability coefficient.
Cite:
B. Soujanya, J. Geethanjali, D. Mounika, V. Saikishore. Influence of Casting Solvent and Polymer on Permeability of Propranolol Hydrochloride Through Eudragit RL100 and Eudragit RLPO Films. Res. J. Pharm. Dosage Form. & Tech. 7(1): Jan.-Mar. 2015; Page 69-73
[View HTML]      [View PDF]



Visitor's No. :   166508