Volume No. :   6

Issue No. :  2

Year :  2014

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Formulation and Evaluation of Fast Dissolving Oral Films of Perindopril

Address:   Y. Raja Jayarao, D. Deborah*, T. Ambedkar, S. Manohar Babu
Department of Pharmaceutics, SIMS College of Pharmacy, Mangaldas Nagar, Guntur-522 002 (A.P.)
*Corresponding Author

Over the recent past, many of the research groups are focusing their research on Fast Dissolving Dosage forms technology. However some patients, particularly pediatric and geriatric patients, have difficulty in swallowing or chewing solid dosage forms or willing to take these solid preparations due to fear of choking. The main advantages of FDOF’S are towards pediatric and geriatric patients population. Where the difficulty of swallowing a larger oral dose is a main problem. This technology has been used for local action, rapid release products and for bucoadhesive systems that are retained for longer period in the oral cavity to release drug in controlled fashion. FDOF offers an alternate platform for molecules that undergo first pass metabolism and for delivery of peptides. The aim of this study was to develop an innovative Fast Dissolving oral film of (FDOF) of Perindopril. The new dosage form was obtained by solvent casting method using polymers such as Hydroxy propyl methyl cellulose and polyethylene glycol, chitosan. A various concentration of polymers was conducted in order to optimize API concentration of the new dosage form. The FDOF was characterized for weight, thickness, folding endurance and dissolution using invitro experimentations. The effect of HPMC and PEG on drug release profile and film forming properties was investigated. The prepared films exhibited satisfactory physic-chemical characteristics. Finally, it is concluded that Perindopril can be formulated with HPMC, chitosan and PEG polymers to achieve oral film formulation by using solvent casting method.
Perindopril, HPMC, PEG, Chitosan Fast dissolving oral film dosage form.
Y. Raja Jayarao, D. Deborah, T. Ambedkar, S. Manohar Babu. Formulation and Evaluation of Fast Dissolving Oral Films of Perindopril. Res. J. Pharm. Dosage Form. and Tech. 6(2):April- June 2014; Page 71-80.
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