Volume No. :   6

Issue No. :  1

Year :  2014

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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In Vitro Evaluation of Release Modifying Potential of Prunus persica Gum in Matrix Tablets



Address:   Yogesh Joshi1*, Ratendra Kumar Chaudhary2, U.V.S. Teotia3
1Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India.
2Meerut Institute of Engineering and Technology, Meerut, Uttar Pradesh, India.
3Shri Venkateshwara University, Gajraula, Uttar Pradesh, India.
*Corresponding Author
DOI No:

ABSTRACT:
The aim of the study was undertaken to find out the release modifying potential of Prunus persica gum in the formulation of diclofenac sodium matrix tablets. Purified isolated gum was subjected to physicochemical characterization. Four formulations containing Prunus persica gum with each containing 100mg of Diclofenac sodium were prepared by wet granulation method using different drug: gum ratios viz. 1:0.25, 1:0.5, 1:1 and 1:2. Microcrystalline cellulose was used as diluent while magnesium stearate and talc were employed as lubricant and glidant respectively. The prepared formulations were evaluated for pre-compression parameters relevant to granules like angle of repose, bulk density, tapped density, hausner’s index and carr’s index while tablets were evaluated for various post-compression parameters like tablet thickness, hardness, weight variation, friability, content uniformity, disintegration time, swelling behaviour and in-vitro drug release study. All the formulations showed compliance with pharmacopoeial standards and found to be within the limits as per the standards. Among all the formulations, PP-4 showed a slow and complete drug release of 99.61% over a period of 10 hr and thereby exhibited a satisfactory drug release phenomenon. The drug release of all the formulations was found to follow zero order kinetics as correlation coefficient (R2) values are higher than that of first order kinetics.
KEYWORDS:
Diclofenac sodium, Prunus persica, Formulation, Release kinetics, Evaluation.
Cite:
Yogesh Joshi, Ratendra Kumar Chaudhary, U.V.S. Teotia. In Vitro Evaluation of Release Modifying Potential of Prunus persica Gum in Matrix Tablets. Res. J. Pharm. Dosage Form. and Tech. 6(1): Jan.-Mar. 2014; Page 18-25.
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