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Research Journal of Pharmaceutical Dosage Forms and Technology
ISSN: 0975-4377(Online), 0975-234X(Print)
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Formulation and In-Vitro Characterization of Ketorolac Tromethamine Ophthalmic Inserts
S.N. Kothawade*, S.T. Deshpande, A.S. Lunkad, P.A. Dighe
SCSSS’s Sitabai Thite College of Pharmacy, Shirur (Ghodnadi). Dist: Pune- 412210
Ophthalmic inserts are sterile, solid preparations containing drug as dispersion or as solution in the polymeric support. Ketorolac Tromethamine is a nonsteroidal anti- inflammatory drug (NSAID) has a pronounced analgesic, antipyretic and anti-inflammatory action. It is a pyrrole derivative and very effective against disorders of eye. In this study, ophthalmic inserts of Ketorolac Tromethamine were prepared using polymers such as Hydroxypropyl methyl cellulose (HPMC) and Methyl cellulose (MC), and plasticizer such as Polyethylene glycol 400 (PEG) by solvent casting method. The ophthalmic inserts were evaluated for uniformity of thickness, weight, drug content and swelling index. In vitro drug release studies of formulated ocuserts were performed by studying the diffusion through the artificial membrane (prehydrated cellophane). IR spectral studies were performed to confirm the interaction of drug in formulation using KBr disc method. Out of eight formulations prepared, the formulation containing HPMC (1:2) showed complete and prolonged release with 99.91% at the end of 7 hrs.
Ketorolac Tromethamine, ophthalmic inserts, HPMC, MC, In-vitro release.
S.N. Kothawade, S.T. Deshpande, A.S. Lunkad, P.A. Dighe. Formulation and In-Vitro Characterization of Ketorolac Tromethamine Ophthalmic Inserts.Research J. Pharma. Dosage Forms and Tech. 2013; 5(6): 311-314 .
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