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Research Journal of Pharmaceutical Dosage Forms and Technology
ISSN: 0975-4377(Online), 0975-234X(Print)
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Nanocrystals-Universal approach for poorly hydrophilic drug
Shivsambh Narwade*, Dipak Bagad
Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune, Maharashtra, India
The technologies such as high throughput screening, combinatorial chemistry and computer-aided drug design leads to drug candidate with poor solubility, which has erratic absorption and low oral bioavailability. Nanocrystal is universal approach for these drugs. A nanocrystal consists of drug, stabilizers as surfactants or polymers and a liquid dispersion medium which can be aqueous or non-aqueous. The nanocrystals are produced by two approaches i.e. bottom up and top down techniques. The ionic and non-ionic stabilizers avoid aggregation of drug particles by ionic or steric barriers respectively. This review article highlights on nanocrystals, their methods of preparation, special features, role of stabilizers and application of nanocrystals in drug delivery.
Nanocrystals, stabililizer, bottom-up and top-down technique, nanosuspension.
Shivsambh Narwade, Dipak Bagad. Nanocrystals-Universal approach for poorly hydrophilic drug. Research J. Pharma. Dosage Forms and Tech. 2013; 5(5): 245-251.
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