Volume No. :   5

Issue No. :  1

Year :  2013

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Evaluation and marker quantification of antidiabetic herbal tablets: SteviTab and AndroTab by HPLC method



Address:   Anand Chaurasia*, Murli Dhar Kharya
Pharmacognosy and Phytochemistry Laboratory, Department of Pharmaceutical Sciences and Research, Dr. H. S. Gour Central University, Sagar, 470003, M.P., India
*Corresponding Author:
DOI No:

ABSTRACT:
Herbal formulations have reached extensive acceptability as therapeutic agents for several diseases. This study foresees a newer possibility of curing diabetes mellitus, by developing a potential antidiabetic herbal formulation, using bioactive fraction(s) of leaves of S. rebaudiana and whole herb of A. paniculata. The tablets of bioactive butanol fraction of S.rebaudiana and chloroform fraction of A.paniculata was prepared at dose of 450 mg individually and named as SteviTab and AndroTab respectively. For evaluation of prepared tablets various parameters were employed i.e weight variation test, hardness study, friability test, disintegration test and dissolution time study. Though the tablets were made from the standardized fraction, hence quantification of marker in prepared tablet by HPLC method was desirable to undertake chemical characterization and for evaluating the content uniformity in terms of concentration of marker components. Further accelerated stability studies of prepared tablets was performed to examined for the characteristic features i.e. color, mottling, weight variation, hardness and to estimate the amount of the marker compound present in tablet. The results of pre formulation studies revealed that all the values were within acceptable limit. Formulation showed appreciable variation in the weight, hardness, friability, disintegration time and dissolution time of the individual tablet. The presence of markers in the developed mono herbal formulations was quantified by HPLC analysis. Quantification of markers i.e. stevioside and rebaudioside-A, in SteviTab and andrographolide in AndroTab were evaluated. Finally study concludes that prepared herbal formulation passed through evaluating parameters significantly.
KEYWORDS:
Stevioside, rebaudioside-A, andrographolide, antidiabetic, Type-2 diabetes
Cite:
Anand Chaurasia, Murli Dhar Kharya. Evaluation and marker quantification of antidiabetic herbal tablets: SteviTab and AndroTab by HPLC method. Research J. Pharma. Dosage Forms and Tech. 2013; 5(1): 17-21
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