Volume No. :   4

Issue No. :  6

Year :  2012

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Efficient and viable synthesis development for Tiaprofenic Acid in pharmaceutical industries



Address:   Raghubabu K.1*, Mohan N.1, Kalyanaramu B.2, Ramadas C.3 Narayanarao M.3
1Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530003, AP (India)
2Department of Chemistry, Maharajah’s College (Aided & Autonomous), Vizianagaram-535002, AP (India).
3Tyche Industries Limited, 11-15-28, Siris Complex, Doctors Colony, L B Nagar, Hyderabad-500074, India
*Corresponding Author
DOI No:

ABSTRACT:
An industrially efficient method was developed to synthesize of tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1) which is a very important pharmaceutical compound having anti-inflammatory and analgesic activity. Sodium salt of propionitrile is reacted with 5-benzoyl-2-bromothiophene (4) to yield nitrile crude (5) and further hydrolysis to give tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1).
KEYWORDS:
Sodamide, Propionitrile, Anti-inflammatory, Tiaprofenic acid, NSAID
Cite:
Raghubabu K., Mohan N., Kalyanaramu B., Ramadas C. Narayanarao M.. Efficient and viable synthesis development for Tiaprofenic Acid in pharmaceutical industries. Research J. Pharma. Dosage Forms and Tech. 2012; 4(6): 318-319.
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