Volume No. : 4
Issue No. : 6
Year : 2012
ISSN Print : 0975-234X
ISSN Online : 0975-4377
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Subhashis Debnath1*, G. Vijay Kumar2, Debarshi Datta1, D. Swetha1, M. Niranjan Babu1.
1Seven Hills College of Pharmacy, Tirupati, 517 561, A.P, India
2Vikas Institute of Pharmaceutical Sciences, Andhra Pradesh, India.
*Corresponding Author
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DOI No:
ABSTRACT:
Chronopharmaceutics has been described as a branch of pharmaceutics devoted to the design and evaluation of drug delivery system that release a bioactive agent at a rhythm that ideally matches the biological requirement of a given drug therapy. The circadian clock acts like a multifunction timer to regulate homeostatic systems such as sleep and activity, hormone levels, appetite, and other bodily functions with 24h cycles. Diseases such as hypertension, asthma, peptic ulcer, arthritis, etc, follow the body’s circadian rhythm. The goal in drug delivery research is to develop formulations to meet therapeutic needs relating to particular pathological conditions. Research in the chronopharmacological field has demonstrated the importance of biological rhythm in drug therapy, and this has brought a new approach to the drug delivery systems. The application of biological rhythm to pharmacotherapy may be correlated by the appropriate timing of dosing of these drug delivery systems to synchronize drug concentrations to rhythms in disease state.
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KEYWORDS:
Chronopharmaceutics, bioactive agent, circadian clock, circadian rhythm, chronopharmacological, Pharmacotherapy
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Cite:
Subhashis Debnath, G. Vijay Kumar, Debarshi Datta, D. Swetha, M. Niranjan Babu. Chronopharmaceutics as a novel approach for clinically relevant drug delivery system. Research J. Pharma. Dosage Forms and Tech. 2012; 4(6): 309-317.
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