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Research Journal of Pharmaceutical Dosage Forms and Technology
ISSN: 0975-4377(Online), 0975-234X(Print)
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Formulation Development and Evaluation of Orodispersible Tablet of Omeprazole by Using Co-Processed Superdisintegrant.
Sharad A. More
Shrinivas K. Mohite
Sharad A. More, Shrinivas K. Mohite
Department of Quality Assurance, Rajarambapu College of Pharmacy, Kasegaon, Sangli, India.
In the present study, novel co-processed superdisintegrants were developed by solvent evaporation method using crospovidone and crosscarmellose sodium in different ratios (1:1, 1:3 and 3:1) for use in the fast dissolving tablet formulations. The developed excipients were evaluated for angle of repose, Carr’s index and Hausner’s ratio in comparison with physical mixture of superdisintegrants. The angle of repose of the developed excipients was found to be <23o, Carr’s index in the range of 11-21% and Hausner’s ratio in the range of 1.13-1.6. ordispersible tablets of omeprazole were prepared using the above co-processed superdisintegrants and evaluated for pre-compression and post-compression parameters. Based on in vitro dispersion time (approximately 21sec), promising formulation CP1 was tested for in vitro drug release pattern in pH 6.8 Phosphate buffer, drug excipient interaction (IR spectroscopy). Among the designed formulations, the formulation (CP1) containing 6% w/w of co processed superdisintegrant (1:1 mixture of crospovidone and croscarmellose sodium) emerged as the overall best formulation based on drug release characteristics in pH 6.8 phosphate buffer compared to commercial conventional tablet formulation.
co-processed super disintegrant, Omeprazole, Oro dispersible tablet, crospovidone and croscarmellose sodium..
Sharad A. More, Shrinivas K. Mohite. Formulation Development and Evaluation of Orodispersible Tablet of Omeprazole by Using Co-Processed Superdisintegrant.. Research J. Pharma. Dosage Forms and Tech. 2012; 4(4): 216-220.
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