Volume No. :   4

Issue No. :  2

Year :  2012

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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In-vitro evaluation of Captopril tablets present in Yemen markets



Address:   Maged Alwan Noman, Mahmood Albooryhi, Abduwaly Ahmad Sayf, and Hussein Omer Kadi
Department of Pharmaceutics. Faculty of Pharmacy, Sana’a University. Yemen
*Corresponding Author
DOI No:

ABSTRACT:
To investigate the quality of drug content and in vitro availability of different brands of Captopril tablet collected from different retail pharmacy in Sana'a (Yemen). The quality and physicochemical equivalence of fifteen different brands were assessed. The assessment included the evaluation of uniformity of weigh, friability, crushing strength, disintegration and dissolution tests as well as chemical assay according to the Pharmacopoeia. All fifteen brands Captopril showed acceptable uniformity of weight, crushing strength except brand D, friability except brand C and disintegration time. All brands passed the dissolution test at 20 min. where brand D with the lower limit and this may be due to the nature of excipients used or the formulation process. All brands passed the test of Captopril contents except brand B and O. where the amount of Captopril in the two brand are relatively small, which means any demixing or segregation during processing result in non-uniformity of content. It was concluded that Captopril tablets marketed in Sana’a - Yemen are of variance quality. In-vitro study indicated that drug content and dissolutions profiles, are the most important quality control parameters, are still concern for solid pharmaceutical..
KEYWORDS:
Captopril, Yemen, market, in-vitro study and dissolution.
Cite:
Maged Alwan Noman, Mahmood Albooryhi, Abduwaly Ahmad Sayf, Hussein Omer Kadi . In-vitro evaluation of Captopril tablets present in Yemen markets. Research J. Pharma. Dosage Forms and Tech. 2012; 4(2): 124-127 .
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