Volume No. :   4

Issue No. :  1

Year :  2012

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Enhancement of Solubility of Trimethoprim IP by Using Different Surfactants

Address:   Mahendra Deshpande, Chandrashekhara S.*, Nagesh C., Mitul Patel, Sandip Patel and Vivek Majethiya
Maratha Mandal’s College of Pharmacy, Belgaum (Karnataka)
*Corresponding Author

Surface active agents are most widely used in Pharma industry and are having multiple roles due to its versatile nature. In the present study, Drug surfactant delivery systems (DSDS) are prepared of the trimethoprim. Four different surfactants are used for preparing drug surfactant delivery systems at the two different concentrations of each, Brij -30 (0.01%, 0.05%), Cetomacragol-1000 (0.01%, 0.05%), Ethoxylated cardanol-C25 (0.01%, 0.05%) and Ethoxylated cardanol-C30 (0.01%, 0.05%).Tablets are prepared with these DSDS. Evaluation tests of the tablets were done like hardness, weight variation, friability, content uniformity, disintegration test, dissolution test and stability studies. Evaluation tests showed that the formulations having drug along with Ethoxylated cardanol-C25 and Ethoxylated cardanol-C30, were found to be the best formulations with more than 99%-100% release data due to higher hydrophilicity and good surface tension lowering ability of the surfactants.
Drug surfactant delivery system, trimethoprim, surfactant.
Mahendra Deshpande, Chandrashekhara S, Nagesh C., Mitul Patel, Sandip Patel ,Vivek Majethiya. Enhancement of Solubility of Trimethoprim IP by Using Different Surfactants. Research J. Pharma. Dosage Forms and Tech. 2012; 4(1): 48-51.
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