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Research Journal of Pharmaceutical Dosage Forms and Technology
ISSN: 0975-4377(Online), 0975-234X(Print)
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Formulation and in-vitro Evaluation of Indomethacin Microcapsules
T.V.Rao1*, S.Vidhyadhara2 and Dr. Prof. K.R.S. Sambasivarao3
1Associate Professor, Bapatla College of Pharmacy, Bapatla, Guntur District, Andhra Pradesh- 522101
2Professor and Principal, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh.
3Head Deportment of Biotechnology, Achrya Nagarjuna University, Gunter, Andhra Pradesh.
The objective of this research was to formulate and evaluate the Indomethecin microcapsules for controlled drug delivery by emulsification solvent evaporation technique, employing Eutragit RL100 as coating material. Prepared microcapsules were evaluated for average particle size, Flow properties, Microencapsulation efficiency and invitro drug release studies. The drug-polymer interaction evaluated by FT-IR spectroscopy. They were found to be discrete, free flowing high percentage of drug entrapment efficiency and also retard the release for 12 hrs. The in vitro dissolution study confirmed that the formulations followed zero order kinetics and peppas release mechanism.
Indomethacin, Eudragit RL 100,MicroCapsues,FT-IR
T.V.Rao, S.Vidhyadhara, K.R.S. Sambasivarao. Formulation and in-vitro Evaluation of Indomethacin Microcapsules. Research J. Pharma. Dosage Forms and Tech. 2012; 4(1):44-47 .
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