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Research Journal of Pharmaceutical Dosage Forms and Technology
ISSN: 0975-4377(Online), 0975-234X(Print)
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Solid Lipid Nanoparticles: A Promising Nanotechnology
Akshat Sharma, Amit Dubey and Reenu Yadav
Ravi Shankar College of Pharmacy, Bhopal (M.P.)
Solid lipid nanoparticle is one of the rapidly developing fields of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. Solid lipid nanoparticle have their unique size-dependent properties, lipid nanoparticle offer the possibility to develop new therapeutics. Solid lipid Nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers towards them. This review focuses mainly over a broad treatment of Solid lipid nanoparticle discussing their advantages, limitations and their possible remedies. The different types of nanocarriers, which were based on solid lipids like Solid lipid nanoparticle, nano structured lipid carriers, and lipid drug conjugates are discussed with their structural differences. Different methodologies, which are suitable for large scale production and applications of Solid lipid nanoparticle, are described in the article. Appropriate analytical techniques for characterization of Solid lipid nanoparticle like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are highlighted. Various aspects like route of administration and their biodistribution are also incorporated. If appropriately investigated, Solid lipid nanoparticle may open new possibilities and probabilities in therapy of complex diseases.
Solid Lipid Nanoparticles: A Promising Nanotechnology. Akshat Sharma, Amit Dubey ,Reenu Yadav. Research J. Pharma. Dosage Forms and Tech. 2011; 3(5): 167-175 .
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