Volume No. :   3

Issue No. :  4

Year :  2011

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Formulation and Evaluation of Mycophenolate mofetil Capsules



Address:   Akelesh T.*, R. Ramya, Venkatesh. P., Divya Jacob and R. Venkatnarayanan
Department of Pharmaceutics, R.V.S. College of Pharmaceutical Sciences, Trichy Road, Coimbatore-641402
*Corresponding Author
DOI No:

ABSTRACT:
Mycophenolate Mofetil is an immunosuppressant drug used in treatment of systemic lupus erythematosus and in organ transplantation in doses ranging from 180mg to 500mg. Preformulation studies including micromeritic properties of pure drug and drug excipient compatibility studies using DSC were performed. Formulation was done by Wet Granulation process. The physical properties of the blend like LOD, Bulk density, Compressibility index, Hausner ratio, and Sieve analysis were tested and the finished product were evaluated for Invitro drug release profile, Weight variation, Thickness, and Stability studies. The dissolution profile of the formulated capsules was compared with Innovator product. The release rate was identical to that of Innovator product.
KEYWORDS:
Mycophenolate mofetil, immunosuppressant, Wet granulation process, Pregelatinized starch
Cite:
Akelesh T., R. Ramya, Venkatesh. P., Divya Jacob , R. Venkatnarayanan. Formulation and Evaluation of Mycophenolate mofetil Capsules. Research J. Pharma. Dosage Forms and Tech. 2011; 3(4): 148-151.
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