Volume No. :   3

Issue No. :  4

Year :  2011

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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A Validated RP- HPLC Method for Estimation of Risperidone in Oral Solution



Address:   S. Kathirvel and A. Suneetha*.
Hindu College of Pharmacy, Amaravathi Road, Guntur-500 002, A.P, India
DOI No:

ABSTRACT:
A simple, rapid, sensitive and precise HPLC method has been developed for the estimation of risperidone in oral solution. In this method RP-C18 Phenominex Gemini column (250 mm x 4.6 mm i.d.,5µm particle size) with mobile phase consisting of 0.5% ammonium acetate buffer, acetonitrile and methanol in the ratio of 50:20:30 v/v/v in isocratic mode was used. The detection wavelength is 260 nm and the flow rate is 1.5 mL/min. In the range of 20-100µg/mL, the linearity of risperidone shows a correlation coefficient of 0.9999. The percentage recovery ranges from 98.95-101.50%. The proposed method was validated by determining sensitivity, accuracy, precision and linearity.
KEYWORDS:
Risperidone, HPLC, Oral solution,Validation
Cite:
S. Kathirvel , A. Suneetha. A Validated RP- HPLC Method for Estimation of Risperidone in Oral Solution. Research J. Pharma. Dosage Forms and Tech. 2011; 3(4): 139-141.
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