Volume No. :   3

Issue No. :  2

Year :  2011

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Comparative in Vitro Dissolution Assessment of Three Different Brands of Lansoprazole Capsules



Address:   J. Srinivasa Rao1*, J. Naga Mallika1, M. Sri Madhu Sri2, G. Raveendra Babu2, M. Prasada Rao2 and C. Gopinath1
1Hindu College of Pharmacy, Amravati Road, Guntur, Andhrapradesh.
2MAM College of Pharmacy, Narasaraopet, Guntur (Dt), Andhrapradesh.
*Corresponding Author:
DOI No:

ABSTRACT:
The present study has made an attempt to compare % release of three different brands (Lanzol, Lanzap and Lan) of lansoprazole using USP Type II (Paddle) dissolution Apparatus in three Media (phosphate buffer pH 6.0, 6.8 and 7.4). It has been observed from the dissolution profile that more than 90% of Lansoprazole is released from each capsule at 30.0 minutes time point. The F1 and F2 values of Lanzol Vs Lanzap are 7.02% and 59.87%, Lanzol Vs Lan are 1.51% and 81.99% and Lan Vs Lanzop are 0.38% and 59.98% at pH6.0; The F1 and F2 values of Lanzol Vs Lanzap are 7.65% and 55.95%, Lanzol Vs Lan are 3.91% and 69.18%, Lan Vs Lanzop are 3.90% and 61.99% at pH 6.8.The F1 and F2 values of Lanzol Vs Lanzap are 4.12% and 67.10%, Lanzol Vs Lan 2.46%, 72.60%, Lan Vs Lanzop 1.70% and 84.53% at pH 7.4. In all three Media % Release pattern is similar; However in pH 7.4 media % Release is about 100% at 45minutes.
KEYWORDS:
Lansoprazole, Dissolution, UV Method.
Cite:
J. Srinivasa Rao, J. Naga Mallika, M. Sri Madhu Sri, G. Raveendra Babu, M. Prasada Rao, C. Gopinath. Comparative in Vitro Dissolution Assessment of Three Different Brands of Lansoprazole Capsules. Research J. Pharma. Dosage Forms and Tech. 2011; 3(2): 58-66 .
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