Volume No. :   3

Issue No. :  1

Year :  2011

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Gastroretentive Drug Delivery Systems: A Promising Approach



Address:   Yashomita Mehta1*, Sunita Nirban1, Sunil Kumar1, Kuldeep Malodia1, Pankaj Rakha2 and Manju Nagpal3
1Lord Shiva College of Pharmacy, Sirsa.
2Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa.
3Chitkara School of Pharmaceutical Sciences, Chitkara University, Barotiwala (HP).
*Corresponding Author
DOI No:

ABSTRACT:
Controlled release drug delivery system (CRDDS) have been most extensively used to improve therapy of certain drugs, but several physiological difficulties faced with CRDDS is the inability to restrain and remain in the gastric region for several hours which limit the bioavailability of drug. Hence drug delivery systems with prolonged gastric residence time (GRT) are an approach to improve bioavailability of drugs, reduction in dose thereby leading to less side/toxic effects. Many approaches have been utilized in the development of gastric retention drug delivery systems (GRDDS) such as floating system, extended system, high density system, superporus system, bioadhesive system, and magnetic system etc. This review also summarizes the in vitro and in vivo studies to evaluate the performance and application of GRDDS. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.
KEYWORDS:
Gastric retention, effervescent, floating, magnetic.
Cite:
Yashomita Mehta, Sunita Nirban, Sunil Kumar, Kuldeep Malodia, Pankaj Rakha, Manju Nagpal. Gastroretentive Drug Delivery Systems: A Promising Approach. Research J. Pharma. Dosage Forms and Tech. 2011; 3(1): 01-06 .
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